Fachrichtung Chemie und Lebensmittelchemie, Organische Chemie I, Technische Universität Dresden, Bergstrasse 66, 01069, Dresden, Germany.
Angew Chem Int Ed Engl. 2016 Jan 18;55(3):1160-3. doi: 10.1002/anie.201507269. Epub 2015 Dec 4.
A concise and highly enantioselective synthesis of the flavonoids brosimine A, brosimine B, and brosimacutin L is reported for the first time. The key transformation is a single-step conversion of a flavanone into a flavan by means of an asymmetric transfer hydrogenation/deoxygenation cascade.
首次报道了黄酮类化合物布罗西明 A、布罗西明 B 和布罗西马库廷 L 的简洁、高对映选择性合成。关键转化是通过不对称转移氢化/脱氧级联反应，将 flavanone 一步转化为 flavan。
