Hoem Nordhaug Lena, Vik Anne, Hagen Knut, Stovner Lars Jacob, Pedersen Torunn, Gravdahl Gøril Bruvik, Linde Mattias
1 Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway.
2 Department of Neurosurgery, St. Olavs University Hospital, Trondheim, Norway.
Cephalalgia. 2016 Oct;36(11):1009-1019. doi: 10.1177/0333102415618948. Epub 2016 Jul 19.
Background Headache attributed to head injury is claimed to be among the most common secondary headache disorders, yet available epidemiological evidence is scarce. We evaluated the prevalence of headache among individuals previously exposed to head injury by a comparison to an uninjured control group. Methods This population-based historical cohort study used data from hospital records on previous exposure to head injury linked to a large epidemiological survey with data on headache occurrence. Participants without head injury, according to hospital records, were used as controls. The head injuries were classified according to the Head Injury Severity Scale (HISS) and the International Classification of Headache Disorders (ICHD-3 beta). Binary logistic regression was performed to investigate the association between headache and head injury, controlling for potential confounders. Results The exposed group consisted of 940 individuals and the control group of 38,751 individuals. In the multivariate analyses, adjusting for age, sex, anxiety, depression and socioeconomic status, there were significant associations between mild head injury and any headache, migraine, chronic daily headache and medication overuse headache. Conclusion Headache was more likely among individuals previously referred to a hospital for a mild head injury compared to uninjured controls.
归因于头部损伤的头痛被认为是最常见的继发性头痛疾病之一，但现有的流行病学证据却很匮乏。我们通过与未受伤的对照组进行比较，评估了既往有头部损伤的个体中头痛的患病率。方法：这项基于人群的历史性队列研究使用了医院记录中既往头部损伤的数据，并将其与一项关于头痛发生情况的大型流行病学调查数据相联系。根据医院记录，无头部损伤的参与者被用作对照。头部损伤根据头部损伤严重程度量表（HISS）和国际头痛疾病分类（ICHD-3 beta）进行分类。进行二元逻辑回归以研究头痛与头部损伤之间的关联，并控制潜在的混杂因素。结果：暴露组由940名个体组成，对照组由38751名个体组成。在多变量分析中，调整年龄、性别、焦虑、抑郁和社会经济地位后，轻度头部损伤与任何头痛、偏头痛、慢性每日头痛和药物过度使用性头痛之间存在显著关联。结论：与未受伤的对照组相比，既往因轻度头部损伤而住院的个体更易出现头痛。
