Department of Clinic and Molecular Sciences-Histology, Polytechnic University of Marche, Via Tronto 10/a-60126 Torrette, Ancona, Italy.
Department of Clinical and Molecular Sciences, Division of Endocrinology, School of Medicine, Polytechnic University of Marche, Ancona, Italy.
Inflammation. 2016 Apr;39(2):632-42. doi: 10.1007/s10753-015-0288-9.
In this study, we investigate the relation between vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (iNOS) in periodontal disease of diabetic and non-diabetic individuals. We evaluated immunohistochemical VEGF and iNOS expressions in gingival biopsies from healthy individuals (no chronic periodontitis (CP)), patients with periodontitis alone (CP), patients with diabetes alone (DM) and diabetic patients with chronic periodontitis (DM + CP). We found a significant positive correlation between VEGF and iNOS expression in non-diabetic groups, but not in diabetic ones. Periodontal clinical parameters were not found to be significantly correlated with the inflammatory markers in no-CP, CP, and DM groups, whereas in DM + CP, positive and significant correlations were found between all the considered periodontal parameters and epithelial VEGF and endothelial iNOS. The uncoupling of VEGF and iNOS expression in diabetic individuals could allow a greater involvement of the markers in the inflammatory process of periodontitis.
在这项研究中，我们研究了血管内皮生长因子 (VEGF) 和诱导型一氧化氮合酶 (iNOS) 在糖尿病和非糖尿病个体牙周病中的关系。我们评估了来自健康个体（无慢性牙周炎 (CP)）、仅患有牙周炎的患者 (CP)、仅患有糖尿病的患者 (DM) 和患有糖尿病合并慢性牙周炎的患者 (DM+CP) 的牙龈活检中的免疫组织化学 VEGF 和 iNOS 表达。我们发现非糖尿病组中 VEGF 和 iNOS 表达之间存在显著正相关，但在糖尿病组中则没有。在无 CP、CP 和 DM 组中，牙周临床参数与炎症标志物之间未发现显著相关性，而在 DM+CP 中，所有考虑的牙周参数与上皮 VEGF 和内皮 iNOS 之间均存在正相关和显著相关性。在糖尿病个体中，VEGF 和 iNOS 表达的解偶联可能使这些标志物更多地参与牙周炎的炎症过程。
