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[Rapid chemiluminescence analysis of the effect of drugs on the functional activity of phagocytosing blood cells].

作者信息

Kalmykov S V, Kazimirovskaia V B, Batunova E V

出版信息

Farmakol Toksikol. 1989 Mar-Apr;52(2):97-100.

PMID:2663543
Abstract

The effects of 46 drugs on luminol-dependent chemiluminescence of human whole blood leucocytes during phagocytosis were studied. Anti-inflammatory agents, antihistaminics and anticoagulants inhibited the chemiluminescent phagocytic response of leucocytes (CPRL) at concentrations comparable with therapeutic ones. LD50/ED50 (CPRL inhibition) factor of 3 is offered as the screening threshold for a number of nonsteroidal anti-inflammatory drugs. The possibility of using anticoagulants and anaprilin for the effect of resorption of myocardial infarction was postulated.

摘要

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