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高尔基体：交互式在线脑图谱。

Golgi: Interactive Online Brain Mapping.

作者信息

Brown Ramsay A, Swanson Larry W

机构信息

Department of Biological Sciences, University of Southern California Los Angeles, CA, USA.

出版信息

Front Neuroinform. 2015 Nov 17;9:26. doi: 10.3389/fninf.2015.00026. eCollection 2015.

DOI:10.3389/fninf.2015.00026
PMID:26635596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4646973/
Abstract

Golgi (http://www.usegolgi.com) is a prototype interactive brain map of the rat brain that helps researchers intuitively interact with neuroanatomy, connectomics, and cellular and chemical architecture. The flood of "-omic" data urges new ways to help researchers connect discrete findings to the larger context of the nervous system. Here we explore Golgi's underlying reasoning and techniques and how our design decisions balance the constraints of building both a scientifically useful and usable tool. We demonstrate how Golgi can enhance connectomic literature searches with a case study investigating a thalamocortical circuit involving the Nucleus Accumbens and we explore Golgi's potential and future directions for growth in systems neuroscience and connectomics.

摘要

高尔基体（http://www.usegolgi.com）是大鼠大脑的一个交互式脑图谱原型，可帮助研究人员直观地与神经解剖学、连接组学以及细胞和化学结构进行交互。大量的“组学”数据促使人们探索新方法，以帮助研究人员将离散的研究结果与神经系统的更大背景联系起来。在此，我们探讨高尔基体的基本原理和技术，以及我们的设计决策如何在构建一个既科学有用又易用的工具的各种限制条件之间取得平衡。我们通过一个研究涉及伏隔核的丘脑皮质回路的案例研究，展示了高尔基体如何增强连接组学文献搜索，并探讨了高尔基体在系统神经科学和连接组学中的潜力以及未来的发展方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c36f/4646973/088f2be97f09/fninf-09-00026-g0015.jpg
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