脂肪酶催化不对称合成（S）-（羟甲基）谷氨酸（HMG）的研究。
Studies on lipase-catalyzed asymmetric synthesis of (S)-(hydroxymethyl)glutamic acid (HMG).
作者信息
Yoshioka Hiromasa, Oikawa Masato
机构信息
Yokohama City University, Seto 22-2, Kanazawa-ku, Yokohama, 236-0027 Japan.
出版信息
Springerplus. 2015 Nov 24;4:726. doi: 10.1186/s40064-015-1503-8. eCollection 2015.
Abstract
(S)-(Hydroxymethyl)glutamic acid was successfully synthesized in total 12 % yield over eight steps from tris(hydroxymethyl)aminomethane hydrochloride (Tris·HCl), employing lipase TL-induced enantioselective acetylation of a prochiral 1,3-diol as the key step.
摘要
以三（羟甲基）氨基甲烷盐酸盐（Tris·HCl）为原料，经八步反应成功合成了（S）-（羟甲基）谷氨酸，总收率为12%，其中利用脂肪酶TL催化前手性1,3-二醇的对映选择性乙酰化反应作为关键步骤。
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