Nargesi Arash Aghajani, Shalchi Majid, Nargesi Reihaneh Aghajani, Sadeghpour Niloofar, Zarifkar Mitra, Mozaffari Majid, Imani Mehrnaz, Esteghamati Alireza, Nakhjavani Manouchehr
Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, Tehran University of Medical Sciences, P.O. Box: 13145-784, Tehran, Iran.
Department of Orthodontics, Faculty of Dentistry, Guilan University of Medical Sciences, Rasht, Guilan, Iran.
Cell Stress Chaperones. 2016 Mar;21(2):361-5. doi: 10.1007/s12192-015-0634-8. Epub 2015 Dec 4.
We aimed to study the relation between plasma levels of stress-induced heat shock protein 70 (HSPA1A) with plasminogen activator inhibitor-1 (PAI-1) and high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (Apo-A1), and HDL-C/Apo-A1 ratio. In a matched case-control study on patients with diabetes (40 patients with albuminuria and 40 without albuminuria matched for age, sex, and body mass index), we observed that plasma levels of HSPA1A and PAI-1 are increased in patients with albuminuria (0.55 ± 0.02 vs. 0.77 ± 0.04 ng/ml, p value <0.001 for HSPA1A; 25.9 ± 2 vs. 31.8 ± 2.4 ng/ml, p value <0.05 for PAI-1). There was a significant correlation between HSPA1A and PAI-1 in diabetic patients without albuminuria (r = 0.28; p value = 0.04), but not in those with albuminuria (r = 0.07; p value = 0.63). No association was found between HSPA1A and HDL-C, between HSPA1A and Apo-A1, or between HSPA1A and HDL-C/Apo-A1 ratio. We concluded that there is a direct correlation between plasma HSPA1A and PAI-1 levels in patients with diabetes, which is lost when they develop albuminuria.
我们旨在研究应激诱导的热休克蛋白70（HSPA1A）的血浆水平与纤溶酶原激活物抑制剂-1（PAI-1）、高密度脂蛋白胆固醇（HDL-C）、载脂蛋白A1（Apo-A1）以及HDL-C/Apo-A1比值之间的关系。在一项针对糖尿病患者的配对病例对照研究中（40例蛋白尿患者和40例无蛋白尿患者，根据年龄、性别和体重指数进行配对），我们观察到蛋白尿患者的HSPA1A和PAI-1血浆水平升高（HSPA1A：0.55±0.02对0.77±0.04 ng/ml，p值<0.001；PAI-1：25.9±2对31.8±2.4 ng/ml，p值<0.05）。在无蛋白尿的糖尿病患者中，HSPA1A与PAI-1之间存在显著相关性（r = 0.28；p值 = 0.04），但在有蛋白尿的患者中无相关性（r = 0.07；p值 = 0.63）。未发现HSPA1A与HDL-C之间、HSPA1A与Apo-A1之间或HSPA1A与HDL-C/Apo-A1比值之间存在关联。我们得出结论，糖尿病患者血浆HSPA1A与PAI-1水平之间存在直接相关性，当他们出现蛋白尿时这种相关性消失。
