German Center for Neurodegenerative Diseases (DZNE) Dresden, and CRTD - Center for Regenerative Therapies Dresden, TU Dresden, Fetscherstraße 105, 01307 Dresden, Germany.
Neuron. 2015 Dec 2;88(5):850-851. doi: 10.1016/j.neuron.2015.11.017.
Manipulating neurotransmitter release from astrocytes neighboring the developing new neurons in the course of adult hippocampal neurogenesis, Sultan et al. (2015) reveal that glial influence on neurogenesis ranges from controlling basic precursor cell function well into the establishment of functional circuitry. This extends the concept of the "neurogenic niche" and its key role into advanced stages of adult neuronal development.
在成年海马神经发生过程中,从发育中的新神经元邻近的星形胶质细胞中操纵神经递质释放,Sultan 等人(2015 年)揭示了胶质细胞对神经发生的影响范围从控制基本前体细胞功能一直延伸到功能性回路的建立。这将“神经发生龛”及其关键作用的概念扩展到了成年神经元发育的高级阶段。