The histopathologic diagnosis and subclassification of Hodgkin's disease.

Although Hodgkin's disease is considered a distinct clinical entity, it exhibits a wide range of histologic and cytologic features. It is important to recognize histologic subtypes and their variants for diagnostic reasons, as well as for their clinical significance. An appreciation of the histologic diversity of Hodgkin's disease may also be critical for the interpretation of data regarding the origin of the RS cell.