van Setten Ellie R H, Martinez-Ferreiro Silvia, Maurits Natasha M, Maassen Ben A M
Center for Language and Cognition Groningen (CLCG), Faculty of Arts, University of Groningen, Groningen, The Netherlands.
Research School of Behavioural and Cognitive Neurosciences (BCN), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Dyslexia. 2016 Feb;22(1):64-82. doi: 10.1002/dys.1519. Epub 2015 Dec 7.
Despite their ample reading experience, higher education students with dyslexia still show deficits in reading and reading-related skills. Lateralized print tuning, the early sensitivity to print of the left parietal cortex signalled by the N1 event-related potential (ERP) component, differs between beginning dyslexic readers and controls. For adults, the findings are mixed. The present study aims to investigate whether print tuning, as indexed by the N1 component, differs between 24 students with dyslexia and 15 non-dyslexic controls. Because handedness has been linked to lateralization, first, a separate analysis was conducted including only right-handed participants (n = 12 in both groups), like in most previous studies. ERPs were measured during a judgement task, requiring visual, phonological, or semantic judgments. In both groups, the N1 was earlier and stronger in the left than in the right hemisphere. However, when only strongly right-handed participants were evaluated, the N1 was less left-lateralized for participants with dyslexia as compared with controls. Participants with dyslexia had longer reaction times during the ERP experiment and performed worse on many reading (-related) tasks. These findings suggest that abnormal print tuning can still be found among higher education students with dyslexia and that handedness should be regarded in the study of print tuning.
尽管有丰富的阅读经验，但患有阅读障碍的高等教育学生在阅读及与阅读相关的技能方面仍表现出缺陷。偏侧化印刷体调节，即由N1事件相关电位（ERP）成分所表明的左顶叶皮质对印刷体的早期敏感性，在初患阅读障碍的读者与对照组之间存在差异。对于成年人而言，研究结果不一。本研究旨在调查由N1成分所索引的印刷体调节在24名患有阅读障碍的学生与15名非阅读障碍对照组之间是否存在差异。由于用手习惯与偏侧化有关，首先，像大多数先前研究那样，单独进行了一项仅包括右利手参与者（两组各n = 12）的分析。在一项判断任务期间测量ERP，该任务需要视觉、语音或语义判断。在两组中，N1在左半球比在右半球出现得更早且更强。然而，当仅评估强右利手参与者时，与对照组相比，患有阅读障碍的参与者的N1偏侧化程度较低。患有阅读障碍的参与者在ERP实验期间的反应时间更长，并且在许多（与阅读相关的）任务上表现更差。这些发现表明，在患有阅读障碍的高等教育学生中仍可发现异常的印刷体调节，并且在用手习惯应在印刷体调节研究中予以考虑。
