Seyedan Atefehalsadat, Alshawsh Mohammed Abdullah, Alshagga Mustafa Ahmed, Koosha Sanaz, Mohamed Zahurin
Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia ; School of Biomedical Sciences, Faculty of Science, University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor, Malaysia.
Evid Based Complement Alternat Med. 2015;2015:973143. doi: 10.1155/2015/973143. Epub 2015 Nov 10.
Obesity is recognized as a major life style disorder especially in developing countries and it is prevailing at an alarming speed in new world countries due to fast food intake, industrialization, and reduction of physical activity. Furthermore, it is associated with a vast number of chronic diseases and disabilities. To date, relatively effective drugs, from either natural or synthetic sources, are generally associated with serious side effects, often leading to cessation of clinical trials or even withdrawal from the market. In order to find new compounds which are more effective or with less adverse effects compared to orlistat, the drug that has been approved for obesity, new compounds isolated from natural products are being identified and screened for antiobesity effects, in particular, for their pancreatic lipase inhibitory effect. Pancreatic lipase inhibitory activity has been extensively used for the determination of potential efficacy of natural products as antiobesity agents. In attempts to identify natural products for overcoming obesity, more researches have been focused on the identification of newer pancreatic lipase inhibitors with less unpleasant adverse effects. In this review, we consider the potential role of plants that have been investigated for their pancreatic lipase inhibitory activity.
肥胖被公认为是一种主要的生活方式紊乱疾病，尤其是在发展中国家，并且由于快餐摄入、工业化以及体力活动减少，它在新世界国家正以惊人的速度蔓延。此外，它还与大量慢性疾病和残疾相关。迄今为止，相对有效的药物，无论是天然来源还是合成来源，通常都伴有严重的副作用，常常导致临床试验停止甚至退出市场。为了找到比已获批用于治疗肥胖症的药物奥利司他更有效或副作用更小的新化合物，正在鉴定和筛选从天然产物中分离出的新化合物的抗肥胖作用，特别是它们的胰脂肪酶抑制作用。胰脂肪酶抑制活性已被广泛用于测定天然产物作为抗肥胖剂的潜在功效。为了找到克服肥胖的天然产物，更多的研究集中在鉴定副作用较小的新型胰脂肪酶抑制剂上。在这篇综述中，我们考虑了已被研究具有胰脂肪酶抑制活性的植物的潜在作用。
