文化与大脑的联系：消极的年龄刻板印象可预测阿尔茨海默病生物标志物。
A culture-brain link: Negative age stereotypes predict Alzheimer's disease biomarkers.
作者信息
Levy Becca R, Ferrucci Luigi, Zonderman Alan B, Slade Martin D, Troncoso Juan, Resnick Susan M
机构信息
Social and Behavioral Sciences Division, School of Public Health, Yale University.
Longitudinal Studies Section, Translational Gerontology Branch, Gerontology Research Center, National Institute on Aging.
出版信息
Psychol Aging. 2016 Feb;31(1):82-8. doi: 10.1037/pag0000062. Epub 2015 Dec 7.
Although negative age stereotypes have been found to predict adverse outcomes among older individuals, it was unknown whether the influence of stereotypes extends to brain changes associated with Alzheimer's disease. To consider this possibility, we drew on dementia-free participants, in the Baltimore Longitudinal Study of Aging, whose age stereotypes were assessed decades before yearly magnetic resonance images and brain autopsies were performed. Those holding more-negative age stereotypes earlier in life had significantly steeper hippocampal-volume loss and significantly greater accumulation of neurofibrillary tangles and amyloid plaques, adjusting for relevant covariates. These findings suggest a new pathway to identifying mechanisms and potential interventions related to the pathology of Alzheimer's disease.
尽管已发现负面年龄刻板印象可预测老年人的不良后果，但尚不清楚刻板印象的影响是否会扩展至与阿尔茨海默病相关的大脑变化。为探讨这种可能性，我们选取了巴尔的摩纵向衰老研究中无痴呆症的参与者，他们的年龄刻板印象在进行年度磁共振成像和脑尸检数十年前就已得到评估。在对相关协变量进行调整后，那些在生命早期持有更多负面年龄刻板印象的人，其海马体体积损失明显更严重，神经原纤维缠结和淀粉样斑块的积累也明显更多。这些发现提示了一条新途径，可用于识别与阿尔茨海默病病理学相关的机制和潜在干预措施。
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