Centre for Research in Ageing and Cognitive Health, College of Medicine and Health, South Cloisters, St Luke's Campus, University of Exeter, Exeter, EX1 2LU, UK.
NIHR ARC South West Peninsula (PenARC), University of Exeter, Exeter, United Kingdom.
BMC Geriatr. 2022 Aug 4;22(1):641. doi: 10.1186/s12877-022-03336-5.
It is unclear whether people with dementia (PwD) have more negative attitudes toward own aging (ATOA) than people without dementia and what factors influence ATOA among PwD. We investigated whether PwD have more negative ATOA than individuals without dementia and whether cognition and dementia subtype are associated with ATOA in PwD.
Data from the IDEAL and PROTECT studies were used to compare ATOA between 1502 PwD (mean (SD) age = 76.3 (8.5)) and 6377 individuals without dementia (mean (SD) age = 66.1 (7.1)). Linear regressions and ANOVA were used.
PwD reported slightly more negative ATOA than people without dementia; this relationship disappeared after controlling for depression and self-rated health. In PwD more positive ATOA showed negligible associations with better general cognition, memory performance, verbal fluency, and visuospatial ability. However, after adjusting for covariates only better visuospatial ability predicted more positive ATOA. Additional analyses showed that before and after controlling for covariates, individuals with poorer self-reported visual acuity have more negative ATOA. Amongst dementia subtypes, people with Parkinson's disease dementia and dementia with Lewy bodies reported most negative ATOA.
ATOA between PwD and people without dementia do not differ. ATOA in PwD appear to be affected not by cognitive impairment but by other characteristics that vary across dementia subtypes. Among PwD, those with Parkinson's disease dementia and dementia with Lewy bodies may have higher risk of experiencing negative ATOA due to the motor and visual impairments that they experience.
目前尚不清楚痴呆症患者（PwD）是否比非痴呆症患者对自身衰老有更消极的态度（ATOA），以及哪些因素会影响 PwD 的 ATOA。我们调查了 PwD 是否比非痴呆症患者有更消极的 ATOA，以及认知和痴呆症亚型是否与 PwD 的 ATOA 相关。
使用 IDEAL 和 PROTECT 研究的数据，比较了 1502 名痴呆症患者（平均（SD）年龄=76.3（8.5））和 6377 名非痴呆症患者（平均（SD）年龄=66.1（7.1））之间的 ATOA。使用线性回归和 ANOVA 进行分析。
与非痴呆症患者相比，PwD 报告的 ATOA 略为消极；但在控制抑郁和自我报告的健康状况后，这种关系就消失了。在 PwD 中，更积极的 ATOA 与更好的一般认知、记忆表现、言语流畅性和视空间能力呈微弱关联。然而，在调整了协变量后，只有更好的视空间能力可以预测更积极的 ATOA。进一步的分析表明，在调整了协变量前后，自我报告视力较差的个体 ATOA 更消极。在痴呆症亚型中，帕金森病痴呆和路易体痴呆患者报告的 ATOA 最消极。
PwD 和非痴呆症患者之间的 ATOA 没有差异。PwD 的 ATOA 似乎不受认知障碍的影响，而是受其他在不同痴呆症亚型中变化的特征的影响。在 PwD 中，由于帕金森病痴呆和路易体痴呆患者所经历的运动和视觉障碍，他们可能面临更高的 ATOA 消极体验风险。
