Fukuda Junichiro, Abe Takashi, Okuno Takashi, Kobayashi Tamotsu, Kato Keiichi
Kato Ladies Clinic, Tokyo, Japan.
Kato Ladies Clinic, Tokyo, Japan.
Int J Gynaecol Obstet. 2016 Mar;132(3):309-13. doi: 10.1016/j.ijgo.2015.08.001. Epub 2015 Nov 14.
To determine whether the use of a human chorionic gonadotropin (hCG) injection as a follicle-maturation trigger affects a patient's reproductive ability during their subsequent menstrual cycle.
Patients that were infertile undergoing natural-cycle in vitro fertilization at Kato Ladies Clinic, Japan, between March and June 2012 were enrolled in a prospective cohort study. Patients who had received fertility treatments other than hCG injections were excluded from the study. The remaining patients were divided into two cohorts; patients who had received injection-administered hCG (study group) and patients who had not received any fertility treatment (control group) during their preceding menstrual cycle. The rates of oocyte retrieval, fertilization, clinical pregnancy, and live deliveries were analyzed using a Fisher exact test.
The rate of successful oocyte-retrieval (P<0.001) and the delivery-rate (P=0.002) were significantly lower in the study group in comparison with the control group. Additionally, the incidence of empty follicles (P<0.001) and degenerated oocytes (P=0.002) was significantly higher in the exposure group.
Triggering follicle maturation with hCG during in vitro fertilization could impact patient fertility during their next cycle. Treatment with hCG injection has the potential to influence not only the cycle during which it is administered, but also the subsequent menstrual cycle.
确定使用人绒毛膜促性腺激素（hCG）注射作为卵泡成熟触发因素是否会影响患者随后月经周期的生殖能力。
2012年3月至6月间，在日本加藤女子诊所接受自然周期体外受精的不孕患者被纳入一项前瞻性队列研究。接受过hCG注射以外生育治疗的患者被排除在研究之外。其余患者分为两个队列；在前一个月经周期接受过注射用hCG的患者（研究组）和未接受任何生育治疗的患者（对照组）。使用Fisher精确检验分析卵母细胞取出率、受精率、临床妊娠率和活产率。
与对照组相比，研究组的成功卵母细胞取出率（P<0.001）和分娩率（P=0.002）显著较低。此外，暴露组的空卵泡发生率（P<0.001）和退化卵母细胞发生率（P=0.002）显著较高。
体外受精期间用hCG触发卵泡成熟可能会影响患者下一个周期的生育能力。hCG注射治疗不仅有可能影响给药周期，还可能影响随后的月经周期。
