Xia Ju-Feng, Inagaki Yoshinori, Zhang Jian-Feng, Wang Ling, Song Pei-Pei
Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan.
Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Fudan University Shanghai Medical College, Shanghai, 200011, China.
Chin J Integr Med. 2017 Apr;23(4):245-252. doi: 10.1007/s11655-016-2510-5. Epub 2016 Aug 2.
Chinese medicine (CM) has been used in clinical treatment for thousands of years in China, Japan, Korea, and other countries. CM is at present attracting many attentions around the world for reproductive health care and disease prevention, including treatment of female infertility. This review focuses on the CM treatment for female infertility patients, and supplies a summary on the efficacy, safety, and mechanism of some Chinese herbal medicines, herbal medicine-derived active compounds, and acupuncture. A large number of researches have reported that CM could alleviate or even cure female infertility by regulating hormone, improving reproductive outcome of in vivo fertilization, affecting embryonic implantation, curing polycystic ovarian syndrome, endometriosis, pelvic inflammatory disease, relieving mental stress, and regulating immune system. Meanwhile, a few studies claimed that there was little adverse reaction of CM in randomized controlled trials. However, up to present there is a lack of adequate evidences with molecular mechanistic researches and randomized controlled trials to prove the CM as an effective and safe treatment for infertility. Thus, utility of CM as a complementary medicine will be a feasible method to improve the outcome of female infertility treatment.
中医在中国、日本、韩国及其他国家已应用于临床治疗数千年。目前，中医在全球范围内因生殖保健和疾病预防，包括治疗女性不孕症，正吸引着诸多关注。本综述聚焦于中医对女性不孕症患者的治疗，并总结了一些中药、中药衍生活性化合物及针灸的疗效、安全性和作用机制。大量研究报告称，中医可通过调节激素、改善体内受精的生殖结局、影响胚胎着床、治疗多囊卵巢综合征、子宫内膜异位症、盆腔炎、缓解精神压力及调节免疫系统来缓解甚至治愈女性不孕症。同时，一些研究称在随机对照试验中中医几乎没有不良反应。然而，截至目前，缺乏足够的分子机制研究和随机对照试验证据来证明中医是一种治疗不孕症有效且安全的方法。因此，将中医作为辅助医学使用将是提高女性不孕症治疗效果的一种可行方法。
