Marcé Patricia, Lynch James, Blacker A John, Williams Jonathan M J
Department of Chemistry, University of Bath, Claverton Down, BA2 7AY, Bath, England.
Institute of Process Research & Development, School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK.
Chem Commun (Camb). 2016 Jan 25;52(7):1436-8. doi: 10.1039/c5cc08714g.
A simple, mild and general procedure for the hydration of nitriles to amides using copper as catalyst and promoted by N,N-diethylhydroxylamine is described. The reaction can be conducted in water at low temperature in short reaction times. This new procedure allows amides to be obtained from a wide range of substrates in excellent yields.
描述了一种使用铜作为催化剂并由N，N-二乙羟胺促进的将腈水合为酰胺的简单、温和且通用的方法。该反应可以在低温下于水中在短反应时间内进行。这种新方法能够以优异的产率从多种底物获得酰胺。
