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用聚γ-谷氨酸预处理的生长猪对口蹄疫病毒疫苗的体液抗体反应增强。

Increased humoral antibody response of foot-and-mouth disease virus vaccine in growing pigs pre-treated with poly-γ-glutamic acid.

作者信息

Lee Jee-Hoon, Kang Ik-Jae, Kim A-Reum, Noh You-Sun, Chung Hee-Chun, Park Bong-Kyun

机构信息

Department of Veterinary Medicine Virology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul 08826, Koreaiversity, Seoul 08826, Korea.

出版信息

J Vet Sci. 2016 Jun 30;17(2):253-6. doi: 10.4142/jvs.2016.17.2.253.

DOI:10.4142/jvs.2016.17.2.253
PMID:26645341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4921674/
Abstract

This study was conducted to determine if humoral antibody response of foot-and-mouth disease (FMD) vaccine improved in 8-week-old growing pigs born to well-vaccinated sows pre-treated with 60 mg of poly-γ-glutamic acid (γ-PGA) three days before vaccination. Antibody against FMD virus serotype O was measured 0, 2, 4 and 6 weeks post-vaccination, using a PrioCHECK FMDV type O ELISA kit. The results showed that positive antibody reactions against FMDV serotype O antigen among a component of the vaccine significantly increased in response to pre-injection with γ-PGA.

摘要

本研究旨在确定在接种疫苗前三天用60毫克聚γ-谷氨酸（γ-PGA）预处理的、接种过疫苗的母猪所产8周龄生长猪中，口蹄疫（FMD）疫苗的体液抗体反应是否得到改善。使用PrioCHECK FMDV O型ELISA试剂盒在接种疫苗后0、2、4和6周测量针对口蹄疫病毒O型的抗体。结果表明，预先注射γ-PGA后，疫苗成分中针对口蹄疫病毒O型抗原的阳性抗体反应显著增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c411/4921674/b205b111219c/jvs-17-253-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c411/4921674/b205b111219c/jvs-17-253-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c411/4921674/b205b111219c/jvs-17-253-g001.jpg

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Dietary germanium biotite supplementation enhances the induction of antibody responses to foot-and-mouth disease virus vaccine in pigs.日粮添加锗云母可增强猪对口蹄疫病毒疫苗抗体反应的诱导。
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Co-administration of flagellin augments immune responses to inactivated foot-and-mouth disease virus (FMDV) antigen.
在猪中产生和维持针对口蹄疫病毒的保护性疫苗诱导免疫反应的挑战
Front Vet Sci. 2016 Nov 30;3:102. doi: 10.3389/fvets.2016.00102. eCollection 2016.
鞭毛蛋白共给药增强了对灭活口蹄疫病毒（FMDV）抗原的免疫应答。
Res Vet Sci. 2013 Dec;95(3):936-41. doi: 10.1016/j.rvsc.2013.07.021. Epub 2013 Aug 12.
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An adenovirus vectored mucosal adjuvant augments protection of mice immunized intranasally with an adenovirus-vectored foot-and-mouth disease virus subunit vaccine.一种腺病毒载体黏膜佐剂增强了经鼻腔免疫接种腺病毒载体口蹄疫病毒亚单位疫苗的小鼠的保护作用。
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