Haneke E, Bolla K, Degreef H, Djawari D, Demaubeuge J, Molin L, Panconesi E, Schöpf E, Stengel R, Stingl G
Int J Clin Pharmacol Res. 1984;4(6):439-43.
Twenty-four patients suffering from longstanding severe recurrent herpes simplex, who had not responded to prior therapy, were treated with s.c. thymopentin injections 50 mg, three times weekly, over a period of six weeks. They were followed up at weekly intervals over this period and then six weeks later. Moreover, the longest relapse-free period observed in the year after the treatment was recorded in the investigator's documentation. Thirteen of the 14 patients with labial herpes simplex and 10 of the 13 patients with genital herpes simplex improved markedly as shown by a decrease in the relapse rate of at least 50%, shorter episodes of relapse and improvement of symptoms such as pain and itching. Fourteen of these 27 patients experienced no relapse for a period longer than four months after cessation of the therapy. No serious side-effects were observed. Laboratory examinations before, during and after thymopentin did not reveal significant alterations except for an increase in the T-helper/T-suppressor ratio. The effect of thymopentin is assumed to be due to T-helper cell activation resulting in enhanced interleukin-2 production with subsequent proliferation of cytotoxic T lymphocytes and natural killer cells which are capable of producing immune interferon.
24例患有长期严重复发性单纯疱疹且对先前治疗无反应的患者，接受了皮下注射胸腺五肽50mg的治疗，每周3次，为期6周。在此期间，每周对他们进行随访，然后在6周后再次随访。此外，治疗后一年内观察到的最长无复发期记录在研究者的文档中。14例唇疱疹患者中有13例，13例生殖器疱疹患者中有10例有明显改善，表现为复发率至少降低50%，复发发作期缩短，疼痛和瘙痒等症状改善。这27例患者中有14例在治疗停止后4个月以上未复发。未观察到严重副作用。胸腺五肽治疗前、治疗期间和治疗后进行的实验室检查未发现明显变化，仅辅助性T细胞/抑制性T细胞比值升高。胸腺五肽的作用被认为是由于辅助性T细胞激活，导致白细胞介素-2产生增加，随后细胞毒性T淋巴细胞和自然杀伤细胞增殖，这些细胞能够产生免疫干扰素。
