用于实时双模成像及监测抗癌药物释放的双光子敏化空心Gd2O3:Eu(3+)纳米复合材料
Two-photon sensitized hollow Gd2O3:Eu(3+) nanocomposites for real-time dual-mode imaging and monitoring of anticancer drug release.
作者信息
Shen Tingting, Zhang Yu, Kirillov Alexander M, Cai Huijuan, Huang Kun, Liu Weisheng, Tang Yu
机构信息
State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Centro de Quimica Estrutural, Complexo I, Instituto Superior Tecnico, Universidade de Lisboa, Av. Rovisco Pais, Lisbon 1049-001, Portugal.
出版信息
Chem Commun (Camb). 2016 Jan 25;52(7):1447-50. doi: 10.1039/c5cc07609a.
New two-photon sensitized multifunctional nanocomposites were designed for dual-mode imaging and real-time drug release monitoring by photoluminescence (PL) and magnetic resonance imaging (MRI). By drug loading based on coordination effect, PL signals of Eu(3+) and MRI signals of Gd(3+) can be stabilized and enhanced, respectively, which then display excellent linear decreases on drug release.
新型双光子敏化多功能纳米复合材料被设计用于通过光致发光（PL）和磁共振成像（MRI）进行双模态成像和实时药物释放监测。基于配位效应进行药物负载，分别可以稳定并增强Eu(3+)的PL信号和Gd(3+)的MRI信号，随后在药物释放时它们会呈现出优异的线性下降。
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