血友病患者中人类嗜T淋巴细胞病毒1型（HTLV-1）的流行情况及其与丙型肝炎病毒（HCV）、乙型肝炎病毒（HBV）和人类免疫缺陷病毒（HIV）的合并感染情况。

The prevalence of HTLV-1 and its Co-Infection with HCV, HBV and HIV in Hemophilic patients.

作者信息

Ziaee Masood, Namaei Mohammad Hassan, Azarkar Ghodseh

机构信息

Masood Ziaee, Hepatitis Research Center, Birjand University of Medical Sciences, Birjand, Iran.

Mohammad Hassan Namaei, Hepatitis Research Center, Birjand University of Medical Sciences, Birjand, Iran.

出版信息

Pak J Med Sci. 2015 Sep-Oct;31(5):1246-9. doi: 10.12669/pjms.315.7888.

DOI:10.12669/pjms.315.7888

PMID:26649023

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4641292/

Abstract

BACKGROUND AND OBJECTIVE

Blood-borne infections, such as the HIV virus and hepatitis B and C, are major problems in patients receiving blood products. Here we examined the prevalence of HTLV-1, HCV, HBV, and HIV in hemophilic patients.

METHODS

A cross-sectional study on 108 hemophilic patients (101 males and 7 females) involved detection of HBV, HCV, HIV and HTLV-1 infections using immunoassays for HBsAg, hepatitis B core antibodies (anti-HBc), hepatitis C antibodies (anti-HCV), HIV antibodies (anti-HIV) and Anti-HTLV-1. Real-time PCR was used to measure HCV RNA, and HCV genotyping was performed by direct sequencing of the 5' noncoding region.

RESULTS

Hemophilia A was reported in 93 (86%) patients with severe symptoms in 8 cases. The seroprevalence of anti-HCV and anti-HTLV-1 antibodies was 20% and 3% respectively. One patient with severe hemophilia had a HCV/HTLV-1 co-infection. HCV-RNA was detected in 82% of patients. In terms of genotyping prevalence was 56% HCV genotype 3a, 39% HCV genotype 1a, and 6% HCV genotype2. Anti HIV and HBsAg were not detected in any patient. HTLV1 prevalence was higher, HCV lower in South Khorasan than other regions in Iran or elsewhere.

CONCLUSION

Management of transfusion of blood and blood products should account for the underlying prevalence of infectious agents.

摘要

背景与目的

血源性感染，如艾滋病毒以及乙型和丙型肝炎，是接受血液制品患者面临的主要问题。在此，我们调查了血友病患者中人类嗜T淋巴细胞病毒1型（HTLV-1）、丙型肝炎病毒（HCV）、乙型肝炎病毒（HBV）和艾滋病毒（HIV）的流行情况。

方法

对108例血友病患者（101例男性和7例女性）进行了一项横断面研究，采用免疫分析法检测HBsAg、乙型肝炎核心抗体（抗-HBc）、丙型肝炎抗体（抗-HCV）、艾滋病毒抗体（抗-HIV）和抗-HTLV-1，以检测HBV、HCV、HIV和HTLV-1感染。采用实时聚合酶链反应（PCR）检测HCV RNA，并通过对5'非编码区进行直接测序进行HCV基因分型。

结果

93例（86%）患者报告为甲型血友病，8例症状严重。抗-HCV和抗-HTLV-1抗体的血清流行率分别为20%和3%。1例重度血友病患者存在HCV/HTLV-1合并感染。82%的患者检测到HCV-RNA。就基因分型而言，流行率为56%的HCV基因型3a、39%的HCV基因型1a和6%的HCV基因型2。未在任何患者中检测到抗艾滋病毒和HBsAg。在伊朗霍拉桑省南部，HTLV-1流行率较高，HCV流行率低于伊朗其他地区或其他地方。