屈光手术后的干眼疾病：高度近视患者中全飞秒激光微小切口基质透镜切除术与飞秒激光制瓣准分子原位角膜磨镶术的12个月随访
Dry Eye Disease following Refractive Surgery: A 12-Month Follow-Up of SMILE versus FS-LASIK in High Myopia.
作者信息
Wang Bingjie, Naidu Rajeev K, Chu Renyuan, Dai Jinhui, Qu Xiaomei, Zhou Hao
机构信息
Key Myopia Laboratory of Chinese Health Ministry, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, No. 83, Fenyang Road, Shanghai 200031, China.
The University of Sydney, Camperdown, NSW 2006, Australia.
出版信息
J Ophthalmol. 2015;2015:132417. doi: 10.1155/2015/132417. Epub 2015 Nov 15.
Purpose. To compare dry eye disease following SMILE versus FS-LASIK. Design. Prospective, nonrandomised, observational study. Patients. 90 patients undergoing refractive surgery for myopia were included. 47 eyes underwent SMILE and 43 eyes underwent FS-LASIK. Methods. Evaluation of dry eye disease was conducted preoperatively and at 1, 3, 6, and 12 months postoperatively, using the Salisbury Eye Evaluation Questionnaire (SEEQ) and TBUT. Results. TBUT reduced following SMILE at 1 and 3 months (p < 0.001) and at 1, 3, and 6 months following FS-LASIK (p < 0.001). TBUT was greater following SMILE than FS-LASIK at 3, 6, and 12 months (p < 0.001, p < 0.001, and p = 0.009, resp.). SEEQ scores increased (greater symptoms) following SMILE at 1 month (p < 0.001) and 3 months (p = 0.003) and at 1, 3, and 6 months following FS-LASIK (p < 0.001). SMILE produced lower SEEQ scores (fewer symptoms) than FS-LASIK at 1, 3, and 6 months (p < 0.001). Conclusion. SMILE produces less dry eye disease than FS-LASIK at 6 months postoperatively but demonstrates similar degrees of dry eye disease at 12 months.
目的。比较全飞秒激光微小切口基质透镜切除术（SMILE）与飞秒激光制瓣准分子原位角膜磨镶术（FS-LASIK）后的干眼疾病情况。设计。前瞻性、非随机、观察性研究。患者。纳入90例接受近视屈光手术的患者。47只眼接受了SMILE手术，43只眼接受了FS-LASIK手术。方法。术前及术后1、3、6和12个月，使用索尔兹伯里眼评估问卷（SEEQ）和泪膜破裂时间（TBUT）对干眼疾病进行评估。结果。SMILE术后1个月和3个月时TBUT降低（p<0.001），FS-LASIK术后1、3和6个月时TBUT降低（p<0.001）。在3、6和12个月时，SMILE术后的TBUT大于FS-LASIK术后（分别为p<0.001、p<0.001和p = 0.009）。SMILE术后1个月（p<0.001）和3个月（p = 0.003）以及FS-LASIK术后1、3和6个月时SEEQ评分升高（症状更严重）（p<0.001）。在1、3和6个月时，SMILE产生的SEEQ评分（症状更少）低于FS-LASIK（p<0.001）。结论。SMILE术后6个月时产生的干眼疾病比FS-LASIK少，但在12个月时干眼疾病程度相似。
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