克服癌症干细胞中的多药耐药性。
Overcoming Multidrug Resistance in Cancer Stem Cells.
作者信息
Moitra Karobi
机构信息
Department of Biology, College of Arts and Sciences, Trinity Washington University, 125 Michigan Avenue NE, Washington, DC 20017, USA.
出版信息
Biomed Res Int. 2015;2015:635745. doi: 10.1155/2015/635745. Epub 2015 Nov 16.
The principle mechanism of protection of stem cells is through the expression of ATP-binding cassette (ABC) transporters. These transporters serve as the guardians of the stem cell population in the body. Unfortunately these very same ABC efflux pumps afford protection to cancer stem cells in tumors, shielding them from the adverse effects of chemotherapy. A number of strategies to circumvent the function of these transporters in cancer stem cells are currently under investigation. These strategies include the development of competitive and allosteric modulators, nanoparticle mediated delivery of inhibitors, targeted transcriptional regulation of ABC transporters, miRNA mediated inhibition, and targeting of signaling pathways that modulate ABC transporters. The role of ABC transporters in cancer stem cells will be explored in this paper and strategies aimed at overcoming drug resistance caused by these particular transporters will also be discussed.
干细胞的主要保护机制是通过ATP结合盒（ABC）转运蛋白的表达。这些转运蛋白是体内干细胞群体的守护者。不幸的是，正是这些ABC外排泵为肿瘤中的癌症干细胞提供了保护，使它们免受化疗的不良影响。目前正在研究多种规避这些转运蛋白在癌症干细胞中功能的策略。这些策略包括开发竞争性和变构调节剂、纳米颗粒介导的抑制剂递送、ABC转运蛋白的靶向转录调控、miRNA介导的抑制以及靶向调节ABC转运蛋白的信号通路。本文将探讨ABC转运蛋白在癌症干细胞中的作用，并讨论旨在克服由这些特定转运蛋白引起的耐药性的策略。
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