Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran.
Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran; Center of Excellence on Biomaterials, Amirkabir University of Technology, Tehran, Iran.
J Control Release. 2014 Jul 10;185:22-36. doi: 10.1016/j.jconrel.2014.04.015. Epub 2014 Apr 18.
The field of nanochemistry research has shown a great progress in the developing of novel nanocarriers as potential drug delivery systems. Niosome is a class of molecular cluster formed by self-association of non-ionic surfactants in an aqueous phase. The unique structure of niosome presents an effective novel drug delivery system (NDDS) with ability of loading both hydrophilic and lipophilic drugs. Numerous research articles have been published in scientific journals, reporting valuable results of individual case studies in this context. However, surveying and discussing the recent, rapidly growing reported studies along with their theoretical principals is required for the fully understanding and exploring the great potential of this approach. To this aim, we have provided an illustrated and comprehensive study from the view of a supramolecular chemist, interested in the synthesizing and studying chemical aggregates on the nanoscale for the development of nanotechnological clusters including niosomes. First, a connectional review of the molecular structure and physicochemical properties of niosome forming non-ionic surfactants and additive agents have been discussed. Second, a systematic survey of niosome preparation and loading methods, administration routes, characterization of niosomes, their toxicity studies and mechanism of drug release; used in recent articles have been performed.
纳米化学研究领域在开发新型纳米载体作为潜在药物传递系统方面取得了很大进展。囊泡是由非离子型表面活性剂在水相中自组装形成的一类分子聚集体。囊泡的独特结构提供了一种有效的新型药物传递系统（NDDS），能够负载亲水性和疏水性药物。许多研究论文已经在科学期刊上发表，报告了这方面的个别案例研究的有价值结果。然而，为了全面理解和探索这种方法的巨大潜力，需要对最近快速增长的报道研究进行调查和讨论，并探讨其理论原理。为此，我们从超分子化学家的角度提供了一个说明性和全面的研究，对在纳米尺度上合成和研究化学聚集体感兴趣，以开发包括囊泡在内的纳米技术聚集体。首先，讨论了形成囊泡的非离子型表面活性剂和添加剂的分子结构和物理化学性质的关联评论。其次，对最近文章中使用的囊泡的制备和负载方法、给药途径、囊泡的表征、毒性研究和药物释放机制进行了系统的调查。
