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依托泊苷耐药和依托泊苷敏感 MCF7 乳腺癌细胞系之间的差异基因和 microRNA 表达。

Differential gene and microRNA expression between etoposide resistant and etoposide sensitive MCF7 breast cancer cell lines.

机构信息

Laboratory of Experimental Immunology, Cancer and Inflammation Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.

出版信息

PLoS One. 2012;7(9):e45268. doi: 10.1371/journal.pone.0045268. Epub 2012 Sep 18.

DOI:10.1371/journal.pone.0045268
PMID:23028896
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3445463/
Abstract

In order to develop targeted strategies for combating drug resistance it is essential to understand it's basic molecular mechanisms. In an exploratory study we have found several possible indicators of etoposide resistance operating in MCF7VP cells, including up-regulation of ABC transporter genes, modulation of miRNA, and alteration in copy numbers of genes.

摘要

为了制定针对耐药性的靶向策略，了解其基本分子机制至关重要。在一项探索性研究中，我们在 MCF7VP 细胞中发现了几个可能的依托泊苷耐药指标，包括 ABC 转运体基因的上调、miRNA 的调节以及基因拷贝数的改变。

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