Slabý J, Stípek S
Sb Lek. 1989 Mar;91(2-3):45-51.
In the organism a part of molecular oxygen is converted into highly reactive radicals (superoxid, hydroxyl radical), which react with biological structures (proteins, nucleic acids, membranes). It is one of the general mechanisms of tissue damage, which occurs e. g. in ischemic reoxygenation, i. e. following intestinal, myocardial infarction; further in the site of inflammation the macrophages release superoxid extracellularly; in acute pancreatitis; in oxygenotherapy and other pathologic conditions. In all tissues there exists a protective system which, under physiological conditions, inactivates the toxic radicals. Enzymes (superoxid dismutase, physiological conditions, inactivates the toxic radicals. Enzymes (superoxid system, alpha-tocopherol, ascorbic acid are part of this system. The concept of tissue damage by radicals enables a new view on etiopathogenesis of some diseases and leads to endeavour to use the acquired knowledge in human medicine.
在生物体内，一部分分子氧会转化为高活性自由基（超氧阴离子、羟自由基），这些自由基会与生物结构（蛋白质、核酸、膜）发生反应。这是组织损伤的一般机制之一，例如在缺血再灌注时会发生，即肠道、心肌梗死后；此外，在炎症部位，巨噬细胞会在细胞外释放超氧阴离子；在急性胰腺炎中；在氧疗及其他病理状况下也会出现。在所有组织中都存在一个保护系统，在生理条件下，该系统会使有毒自由基失活。酶（超氧化物歧化酶等）、生理条件、使有毒自由基失活。酶（超氧化物系统、α-生育酚、抗坏血酸是这个系统的一部分。自由基导致组织损伤的概念为某些疾病的病因发病机制提供了新的视角，并促使人们努力将所获得的知识应用于人类医学。
