Notghi A, Dick J, Smith G, Anderton J L, Chisholm G D
Nuffield Transplant Unit, Western General Hospital, Edinburgh.
Scott Med J. 1989 Jun;34(3):459-62. doi: 10.1177/003693308903400305.
Three year graft survival rates were calculated for 66 patients on cyclosporin and prednisolone immuno-suppression and compared to survival rates for 73 patients on azathioprine and prednisolone. There was a temporary early advantage for the cyclosporin treatment group up to four months post transplant. There was no further significant difference between the two treatment groups with graft survival rate of 81.4% in cyclosporin and 76.7% in azathioprine group at three years post transplant. Fewer of the patients on cyclosporin had acute episodes of rejection. There was no significant difference in serum creatinine or urea at one year, but the haemoglobin level was higher in cyclosporin treated patients. Cyclosporin does not appear to have increased the survival rate significantly in our centre where there is already a high graft survival with azathioprine.
计算了66例接受环孢素和泼尼松龙免疫抑制治疗患者的三年移植存活率，并与73例接受硫唑嘌呤和泼尼松龙治疗患者的存活率进行比较。移植后四个月内，环孢素治疗组有暂时的早期优势。两个治疗组之间没有进一步的显著差异，移植三年后，环孢素组的移植存活率为81.4%，硫唑嘌呤组为76.7%。接受环孢素治疗的患者发生急性排斥反应的次数较少。一年时血清肌酐或尿素没有显著差异，但环孢素治疗患者的血红蛋白水平较高。在我们中心，硫唑嘌呤治疗的移植存活率已经很高，环孢素似乎并没有显著提高存活率。
