Ishiyama Yukako, Murata Hiroshi, Hirasawa Hiroyo, Asaoka Ryo
Invest Ophthalmol Vis Sci. 2015 Dec 1;56(13):7801-7805. doi: 10.1167/iovs.15-17988.
We have previously reported that fixation loss (FL) rates, false-positive (FP) rates, and gaze tracking (GT) parameters (average tracking failure frequency per stimulus [TFF], average blinking frequency [BF], average frequency of eye movements between 1° and 2° [move1-2], between 3° and 5° [move3-5], and equal to or more than 6° [move≥6]) are related to the over- or underestimation of visual field (VF) results. The purpose of the current study was to validate these results by investigating the effect of implementing the GT parameters on the relationship between VF results and optical coherence tomography (OCT) measurements.
Two hundred forty-four eyes of 155 open-angle glaucoma patients were included. Vision fixation during VF tests with the Humphrey Field Analyzer (24-2 SITA standard) was evaluated using the gaze fixation chart at the bottom of the VF printout. Mean total deviation (mTD) values were calculated, and their relationship with OCT-determined circumpapillary retinal nerve fiber layer (cp-RNFL), OCT-determined macular ganglion cell complex (GCC) thickness, and axial length was investigated using the corrected Akaike Information Criterion (AICc) in linear mixed modeling.
In the best model, average total cpRNFL thickness, average total GCC thickness, axial length, FL, FP, move3-5, move≥6, TFF, and BF were selected as significant predictors (mTD = 2.1 + 0.097 × average total cpRNFL thickness + 0.089 × average total GCC thickness - 0.94 × axial length + 2.7 × FL + 7.2 × FP - 7.0 × move3-5 - 1.8 × move≥6 - 4.2 × TFF - 1.7 × BF).
Both GT parameters and classic VF reliability indices had significant influence on the structure-function relationship analysis in glaucoma.
我们之前曾报道，固视丢失（FL）率、假阳性（FP）率以及注视追踪（GT）参数（每个刺激的平均追踪失败频率 [TFF]、平均眨眼频率 [BF]、1°至2°之间的眼球运动平均频率 [move1-2]、3°至5°之间的眼球运动平均频率 [move3-5] 以及等于或大于6°的眼球运动平均频率 [move≥6]）与视野（VF）结果的高估或低估有关。本研究的目的是通过研究实施GT参数对VF结果与光学相干断层扫描（OCT）测量之间关系的影响来验证这些结果。
纳入155例开角型青光眼患者的244只眼睛。使用VF打印输出底部的注视固定图表评估使用 Humphrey 视野分析仪（24-2 SITA 标准）进行VF测试期间的视力固定情况。计算平均总偏差（mTD）值，并使用线性混合模型中的校正赤池信息准则（AICc）研究其与OCT确定的视乳头周围视网膜神经纤维层（cp-RNFL）、OCT确定的黄斑神经节细胞复合体（GCC）厚度以及眼轴长度之间的关系。
在最佳模型中，选择平均总cpRNFL厚度、平均总GCC厚度、眼轴长度、FL、FP、move3-5、move≥6、TFF和BF作为显著预测因子（mTD = 2.1 + 0.097×平均总cpRNFL厚度 + 0.089×平均总GCC厚度 - 0.94×眼轴长度 + 2.7×FL + 7.2×FP - 7.0×move3-5 - 1.8×move≥6 - 4.2×TFF - 1.7×BF）。
GT参数和经典的VF可靠性指标对青光眼的结构-功能关系分析均有显著影响。
