Inooka Taiga, Tomita Ryo, Kominami Taro, Mochizuki Marie, Nishiguchi Koji M, Yuki Kenya
Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Transl Vis Sci Technol. 2025 Apr 1;14(4):6. doi: 10.1167/tvst.14.4.6.
To compare Nidek MP-3 microperimetry and ZEISS Humphrey Field Analyzer (HFA) visual field (VF) results in patients with primary open-angle glaucoma (POAG), classified by VF defect severity and to describe a novel method for simulating sensitivity distribution changes assumed to be due to fixation errors.
This retrospective study used the MP-3 and HFA 10-2 tests to examine the VF in eyes with mild, moderate, or severe POAG, using 68 identical test points. Reliability indices and measurement durations were compared. The relationship between pointwise sensitivities of the devices was analyzed.
Thirty-five eyes from 23 patients (10 mild, 12 moderate, and 13 severe POAG) were evaluated. In the severe POAG group, the MP-3 had a significantly lower false-positive (FP) rate and higher false-negative rate than those of the HFA 10-2 (all, P = 0.03). A significant negative correlation existed between the root mean square error, derived from regression analysis comparing the VF sensitivity between devices at each test point, and VF sensitivity of the MP-3 (P < 0.01). In 18 eyes, a shift in the sensitivity distribution occurred, with a significant correlation between the HFA 10-2 mean deviation and the presence of this shift (P < 0.01).
Reliability indices differed significantly between the two devices in severe POAG cases. A shift in the sensitivity of the test points of the two VF tests was detected in approximately one-half of the eyes.
The MP-3 provides lower FP rates in advanced POAG and may assist in the management of this patient cohort.
比较尼德克MP - 3微视野计与蔡司汉弗莱视野分析仪（HFA）在原发性开角型青光眼（POAG）患者中的视野（VF）结果，按视野缺损严重程度分类，并描述一种模拟假定由注视误差导致的敏感度分布变化的新方法。
这项回顾性研究使用MP - 3和HFA 10 - 2测试，通过68个相同测试点检查轻度、中度或重度POAG患者的视野。比较可靠性指标和测量时长。分析两种设备逐点敏感度之间的关系。
对23例患者的35只眼（10例轻度、12例中度和13例重度POAG）进行了评估。在重度POAG组中，MP - 3的假阳性（FP）率显著低于HFA 10 - 2，假阴性率高于HFA 10 - 2（均P = 0.03）。通过比较各测试点两种设备视野敏感度的回归分析得出的均方根误差与MP - 3的视野敏感度之间存在显著负相关（P < 0.01）。在18只眼中，敏感度分布发生了偏移，HFA 10 - 2平均偏差与这种偏移的存在之间存在显著相关性（P < 0.01）。
在重度POAG病例中，两种设备的可靠性指标存在显著差异。在约一半的眼中检测到两种视野测试的测试点敏感度发生了偏移。
MP - 3在晚期POAG中提供较低的FP率，可能有助于该患者群体的管理。
