Hamilton Glaucoma Center, Shiley Eye Institute, and Viterbi Family Department of Ophthalmology, University of California San Diego, San Diego, California.
Hamilton Glaucoma Center, Shiley Eye Institute, and Viterbi Family Department of Ophthalmology, University of California San Diego, San Diego, California.
Am J Ophthalmol. 2022 Feb;234:91-98. doi: 10.1016/j.ajo.2021.06.038. Epub 2021 Jul 17.
To compare standard reliability metrics and gaze tracking (GT) metrics on the Humphrey field analyzer (HFA).
Retrospective cross-sectional study.
The study was performed at the VA Medical Center, San Diego, and included 494 glaucoma and glaucoma suspect patients who had an HFA 24-2 SITA Fast visual field (VF) performed in both eyes. Standard reliability metrics (fixation loss [FL], false-positive [FP], and false-negative [FN]) were compared to GT metrics (deviations of 1°-2° [M1], deviations of 3°-5° [M3], deviations >6° [M6], and tracking failure frequency [TFF]). The main outcome measures were Spearman rank-based correlation coefficient and area under the receiver operating characteristic (AUROC) curves between standard and GT reliability metrics.
The 95th percentile limits for GT metrics were 66.7% for M1, 67.5% for M3, 49.5% for M6, and 79.8% for TFF. There were statistically significant correlations between standard and GT reliability metrics using the 95th percentile as a binary cutoff for GT metrics. However, low Spearman correlation values and AUROC calculations suggest little clinical significance of the associations. FN increased as VF severity worsened (P < .001). M6 was lower in eyes with mild compared to moderate and advanced VF loss (P = .012).
GT metrics do not have a clinically significant association with standard reliability metrics. Both FN and M6 are influenced by VF severity. Aggregate GT metrics do not aid in reliability assessment. These findings suggest that GT metrics may provide an alternative or complementary measure of VF reliability.
比较标准可靠性指标和注视跟踪（GT）指标在 Humphrey 视野分析仪（HFA）上的表现。
回顾性横断面研究。
该研究在圣地亚哥退伍军人事务医疗中心进行，纳入了 494 名青光眼和疑似青光眼患者，他们的双眼均进行了 HFA 24-2 SITA Fast 视野（VF）检查。将标准可靠性指标（固视丢失[FL]、假阳性[FP]和假阴性[FN]）与 GT 指标（1°-2°的偏差[M1]、3°-5°的偏差[M3]、偏差>6°[M6]和跟踪失败频率[TFF]）进行比较。主要观察指标为标准和 GT 可靠性指标之间的 Spearman 等级相关系数和受试者工作特征（ROC）曲线下面积（AUROC）。
GT 指标的 95%百分位限为 M1 为 66.7%、M3 为 67.5%、M6 为 49.5%和 TFF 为 79.8%。使用 GT 指标的 95%百分位作为二进制截断值时，标准和 GT 可靠性指标之间存在统计学显著相关性。然而，低 Spearman 相关值和 AUROC 计算表明，这些相关性的临床意义较小。FN 随着 VF 严重程度的恶化而增加（P<0.001）。与轻度和中度及晚期 VF 损失相比，M6 在轻度 VF 损失的眼中较低（P=0.012）。
GT 指标与标准可靠性指标没有明显的临床关联。FN 和 M6 均受 VF 严重程度的影响。GT 指标的综合指标无助于评估可靠性。这些发现表明，GT 指标可能提供了一种替代或补充 VF 可靠性的测量方法。
