阿尔及利亚人群样本中rs3732378多态性与新生血管性年龄相关性黄斑变性之间的关联。
Association between rs3732378 polymorphism and neovascular age-related macular degeneration in a sample of Algerian population.
作者信息
Messal Ahlem, Abid Ghania, Abdi Meriem, Idder Aicha, Meroufel Naima, Zemani-Fodil Faouzia, Fodil Mostefa
机构信息
Laboratory of molecular and cellular biology, Université des Sciences et de la Technologie d'Oran Mohamed Boudiaf, USTO-MB, Oran, Algeria.
Thematic Agency for Research in Health Sciences ATRSS, Algeria.
出版信息
Mol Biol Res Commun. 2023;12(2):57-62. doi: 10.22099/mbrc.2023.46767.1809.
Neovascular age-related macular degeneration (nAMD) is a progressive ocular disease, responsible for central visual loss and blindness in elderly population. Increase data demonstrate that genetic factors play an important role in pathogenesis process of this disease. The aim of this study is to investigate the association between rs3732378 polymorphism in gene and nAMD in a sample of Algerian patients. This case-control study consisted of 72 patients with nAMD and 124 control subjects. DNA of participants was extracted using salting out method. Genotyping was carried out using the TaqMan real-time polymerase chain reaction method. Statistical analysis was performed by SPSS.21.0. The prevalence of the risk genotype AA was higher in the nAMD group than in control group (OR=5.02, 95% CI=1.44-17.4, P=0.011). In our sample of Algerian patients, the rs3732378 polymorphism is associated with nAMD. This result may support the role of gene in the pathogenesis of nAMD.
新生血管性年龄相关性黄斑变性（nAMD）是一种进行性眼病，可导致老年人群中心视力丧失和失明。越来越多的数据表明，遗传因素在该疾病的发病过程中起重要作用。本研究的目的是在一组阿尔及利亚患者样本中调查基因中rs3732378多态性与nAMD之间的关联。这项病例对照研究包括72例nAMD患者和124例对照受试者。采用盐析法提取参与者的DNA。使用TaqMan实时聚合酶链反应法进行基因分型。通过SPSS 21.0进行统计分析。nAMD组中风险基因型AA的患病率高于对照组（OR = 5.02，95% CI = 1.44 - 17.4，P = 0.011）。在我们的阿尔及利亚患者样本中，rs3732378多态性与nAMD相关。这一结果可能支持该基因在nAMD发病机制中的作用。
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