与年龄相关性黄斑变性相关的遗传因素调节 AIDS 患者血浆炎症生物标志物水平。

Genetic factors associated with age-related macular degeneration modulating plasma inflammatory biomarker levels in patients with AIDS.

机构信息

Department of Food Engineering, İzmir İnstitute of Technology, Izmir, Turkey.

Department of Epidemiology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

出版信息

Ophthalmic Genet. 2024 Aug;45(4):337-342. doi: 10.1080/13816810.2024.2330380. Epub 2024 Mar 25.

DOI:10.1080/13816810.2024.2330380

PMID:38526161

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11387137/

Abstract

INTRODUCTION

Patients with the acquired immunodeficiency syndrome (AIDS) have an increased prevalence and incidence of intermediate-stage age-related macular degeneration (AMD). Several elevated plasma inflammatory biomarkers are associated with increased incidence of intermediate-stage AMD in this population. We evaluated the association between AMD risk alleles and plasma inflammatory biomarker levels in persons with AIDS.

MATERIALS AND METHODS

Cryopreserved plasma specimens of 229 non-Hispanic White and 252 non-Hispanic blacks from the Longitudinal Study of the Ocular Complications of AIDS cohort were assayed for plasma levels of soluble tumor necrosis factor receptor (sTNFR) 2, interleukin (IL)-18, C × 3motif chemokine ligand 1 (CX3CL1), C-reactive protein (CRP), and soluble CD14 (sCD14). Genotyping included AMD-associated variants rs10801553 and rs800292 for complement factor H (CFH) rs9332739 and rs547154 for complement factor 2 (C2), rs2230199 for C3, rs2285714 for CFI, and rs3732379 and rs3732378 for C × 3motif chemokine receptor 1 (CX3CR1).

RESULTS

In Whites, AMD low-risk CX3CR1 variants (V249I and T280M) were associated with reduced plasma levels of IL-18. In Blacks, AMD low-risk C3 R102G and low-risk CX3CR1 T280M variants were associated with reduced CRP levels.

CONCLUSIONS

Genetic variants in AMD-associated immune genes may influence AMD-associated systemic plasma inflammatory biomarker levels in patients with AIDS.

摘要

简介

获得性免疫缺陷综合征（AIDS）患者中间期年龄相关性黄斑变性（AMD）的患病率和发病率增加。该人群中，几种升高的血浆炎症生物标志物与中间期 AMD 的发病率增加相关。我们评估了 AIDS 患者 AMD 风险等位基因与血浆炎症生物标志物水平之间的关系。

材料和方法

对来自纵向 AIDS 眼部并发症研究队列的 229 名非西班牙裔白人和 252 名非西班牙裔黑人的冷冻血浆标本进行了可溶性肿瘤坏死因子受体（sTNFR）2、白细胞介素（IL）-18、C × 3 基序趋化因子配体 1（CX3CL1）、C 反应蛋白（CRP）和可溶性 CD14（sCD14）的血浆水平检测。基因分型包括 AMD 相关变异 rs10801553 和 rs800292 用于补体因子 H（CFH）rs9332739 和 rs547154 用于补体因子 2（C2），rs2230199 用于 C3，rs2285714 用于 CFI，rs3732379 和 rs3732378 用于 C × 3 基序趋化因子受体 1（CX3CR1）。