Drivalos Alexandros, Chrisofos Michael, Efstathiou Eleni, Kapranou Amalia, Kollaitis Gerasimos, Koutlis Georgios, Antoniou Nick, Karanastasis Dimitrios, Dimopoulos Meletios A, Bamias Aristotelis
Department of Urology, Athens General Hospital "Elpis," Athens, Greece.
2nd Department of Urology, School of Medicine, Sismanoglio Hospital, University of Athens, Athens, Greece.
Urol Oncol. 2016 Apr;34(4):165.e11-8. doi: 10.1016/j.urolonc.2015.10.016. Epub 2015 Dec 2.
To explore the correlation between the expression of α5-integrin, α7-integrin, Ε-cadherin, and N-cadherin in prostate cancer (PCa) and its clinicopathological data including tumor grade and clinical stage.
The expression of α5-integrin, α7-integrin, Ε-cadherin, and N-cadherin was examined in 157 cases of PCa and adjacent normal prostatic tissue by immunohistochemical assay, and the correlation with clinicopathological features was analyzed.
Expressions of α5-integrin, α7-integrin, and Ε-cadherin in PCa were lower than those in normal prostatic tissues (P<0.05). N-cadherin expression was higher in cancer prostatic tissue than in normal prostatic tissues (P<0.05). The reduced expression of α5-integrin, α7-integrin, and Ε-cadherin was related to Gleason score, pathological stage, lymph node metastasis, and prostate-specific antigen level, but it was not associated with positive surgical margins and patient age. The increased expression of N-cadherin was related to Gleason score, pathological stage, lymph node metastasis, and prostate-specific antigen level, but not to age and positive surgical margins. The expression of E-cadherin was highly negatively correlated with that of N-cadherin and also positively correlated with that of α5-integrin and α7-integrin.
The reduced expression of α5-integrin, α7-integrin, and Ε-cadherin and abnormal expression of N-cadherin play an important role in the occurrence and development of PCa. The results indicate that these have potential values in the diagnosis and are predictable indices in the proliferation of PCa.
探讨α5整合素、α7整合素、E-钙黏蛋白和N-钙黏蛋白在前列腺癌（PCa）中的表达与包括肿瘤分级和临床分期在内的临床病理数据之间的相关性。
采用免疫组织化学分析法检测157例PCa及癌旁正常前列腺组织中α5整合素、α7整合素、E-钙黏蛋白和N-钙黏蛋白的表达，并分析其与临床病理特征的相关性。
PCa中α5整合素、α7整合素和E-钙黏蛋白的表达低于正常前列腺组织（P<0.05）。癌组织中N-钙黏蛋白的表达高于正常前列腺组织（P<0.05）。α5整合素、α7整合素和E-钙黏蛋白表达降低与Gleason评分、病理分期、淋巴结转移及前列腺特异性抗原水平有关，但与手术切缘阳性及患者年龄无关。N-钙黏蛋白表达升高与Gleason评分、病理分期、淋巴结转移及前列腺特异性抗原水平有关，但与年龄及手术切缘阳性无关。E-钙黏蛋白的表达与N-钙黏蛋白的表达呈高度负相关，与α5整合素和α7整合素的表达呈正相关。
α5整合素、α7整合素和E-钙黏蛋白表达降低及N-钙黏蛋白表达异常在PCa的发生发展中起重要作用。结果表明，这些指标在PCa的诊断中具有潜在价值，是PCa增殖的可预测指标。
