路易斯酸介导的烯醇亲核试剂对α,β-不饱和铂卡宾的乙烯型加成反应
Lewis Acid Mediated Vinylogous Additions of Enol Nucleophiles into an α,β-Unsaturated Platinum Carbene.
作者信息
Allegretti Paul A, Huynh Khoi, Ozumerzifon Tarik J, Ferreira Eric M
机构信息
Department of Chemistry, University of Georgia , Athens, Georgia 30602, United States.
出版信息
Org Lett. 2016 Jan 4;18(1):64-7. doi: 10.1021/acs.orglett.5b03246. Epub 2015 Dec 14.
Abstract
A variety of substituted indoles and benzofurans are accessed via a platinum catalyzed annulation and vinylogous addition of enol nucleophiles. Several β-dicarbonyl compounds participate in the reaction, as do α-nitro and α-cyano carbonyl species. Subjecting the indole products to acidic conditions results in the formation of fused heterocycles.
摘要
通过铂催化的环化反应以及烯醇亲核试剂的插烯加成反应，可以得到多种取代吲哚和苯并呋喃。几种β-二羰基化合物以及α-硝基和α-氰基羰基化合物都参与了该反应。将吲哚产物置于酸性条件下会导致稠合杂环的形成。
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