涡虫作为衰老模型用于研究体内干细胞与衰老细胞之间的相互作用。
Planarians as a model of aging to study the interaction between stem cells and senescent cells in vivo.
作者信息
Perrigue Patrick M, Najbauer Joseph, Jozwiak Agnieszka A, Barciszewski Jan, Aboody Karen S, Barish Michael E
机构信息
Institute of Bioorganic Chemistry, Polish Academy of Sciences, Poznan, Poland;
Department of Immunology and Biotechnology, University of Pécs, Pécs, Hungary.
出版信息
Pathobiol Aging Age Relat Dis. 2015 Dec 10;5:30052. doi: 10.3402/pba.v5.30052. eCollection 2015.
The depletion of stem cell pools and the accumulation of senescent cells in animal tissues are linked to aging. Planarians are invertebrate flatworms and are unusual in that their stem cells, called neoblasts, are constantly replacing old and dying cells. By eliminating neoblasts in worms via irradiation, the biological principles of aging are exposed in the absence of wound healing and regeneration, making planaria a powerful tool for aging research.
动物组织中干细胞库的耗竭和衰老细胞的积累与衰老有关。涡虫是无脊椎扁虫，其不同寻常之处在于它们的干细胞（称为新细胞）会不断替换衰老和死亡的细胞。通过辐射消除涡虫体内的新细胞，在没有伤口愈合和再生的情况下，衰老的生物学原理得以显现，这使涡虫成为衰老研究的有力工具。
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