Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA.
Department of Pharmacy, Cleveland Clinic, Cleveland, OH, USA.
J Hosp Infect. 2016 Feb;92(2):199-202. doi: 10.1016/j.jhin.2015.10.017. Epub 2015 Nov 6.
Limited data are available on intraventricular vancomycin dosing for meningitis. This study explored clinical characteristics that correlated with cerebrospinal fluid (CSF) concentrations. Over a nine-year period, 13 patients with 34 CSF vancomycin concentrations were evaluated. CSF output and time from dose correlated with CSF vancomycin concentration. No relationship was seen with regards to CSF protein, white blood cell count or glucose.
关于脑膜炎患者的脑室万古霉素给药剂量，目前仅有有限的数据。本研究探讨了与脑脊液（CSF）浓度相关的临床特征。在九年期间，对 13 例患者的 34 份 CSF 万古霉素浓度进行了评估。CSF 排出量和剂量后时间与 CSF 万古霉素浓度相关。CSF 蛋白、白细胞计数或葡萄糖水平与 CSF 万古霉素浓度之间未见相关性。
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