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多关节炎和膜增生性肾小球肾炎作为霍奇金淋巴瘤的副肿瘤表现:一例报告及文献复习

Polyarthritis and membranoproliferative glomerulonephritis as paraneoplastic manifestation of Hodgkin's lymphoma: A case report and literature review.

作者信息

Erlij Daniel, Calderón Beatriz, Rivera Angela, Mella Cristián, Valladares Ximena, Roessler Emilio, Rivera María Teresa, Méndez Gonzalo

机构信息

Sección de Reumotalogía, Hospital del Salvador, Universidad de Chile, Santiago, Chile.

Servicio de Medicina, Hospital del Salvador, Universidad de Chile, Santiago, Chile.

出版信息

Reumatol Clin. 2016 Sep-Oct;12(5):282-4. doi: 10.1016/j.reuma.2015.10.002. Epub 2015 Dec 3.

Abstract

Paraneoplastic syndromes can be presented in multiple ways, which include endocrinological, hematologic, rheumatologic and nephrologic manifestations. While most of the publications described solid tumors as responsible for these manifestations, hematologic neoplasms are important cause to consider as part of the differential diagnosis. We report the case of a 46 year-old man with seronegative symmetric polyarthritis of large and small joints associated with membranoproliferative glomerulonephritis with deposits of immune complexes and acute impairment of renal function, as part of a paraneoplastic syndrome secondary of a classical Hodgkin lymphoma with bone marrow invasion, which reversed completely with chemotherapy treatment.

摘要

副肿瘤综合征可通过多种方式表现出来,包括内分泌、血液、风湿和肾脏方面的表现。虽然大多数出版物将实体瘤描述为这些表现的病因,但血液系统肿瘤也是鉴别诊断中需要考虑的重要病因。我们报告了一例46岁男性病例,该患者患有大小关节血清阴性对称性多关节炎,伴有免疫复合物沉积的膜增生性肾小球肾炎和肾功能急性损害,这是一例继发于伴有骨髓浸润的经典型霍奇金淋巴瘤的副肿瘤综合征的一部分,化疗后完全缓解。

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