Ling Q, Tejada-Simon M V
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA.
Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX, USA; Department of Biology, University of Houston, Houston, TX, USA; Department of Psychology, University of Houston, Houston, TX, USA; Biology of Behavior Institute (BoBI), University of Houston, Houston, TX, USA.
Prog Neuropsychopharmacol Biol Psychiatry. 2016 Apr 3;66:80-86. doi: 10.1016/j.pnpbp.2015.11.013. Epub 2015 Dec 2.
Statins are one of the most popular lipid-lowering drugs (LLDs). Upon oral administration, these drugs are well absorbed by the intestine and effectively used for the treatment of dyslipidemias. Recently, statins are becoming also well-known for their cholesterol-independent effects and their potential use in brain diseases and different types of cancers. While still controversial, recent research has suggested that statin's cholesterol-independent activities work possibly through alterations on isoprenoid levels. This reduction of isoprenoids in the central nervous system might result in effective biochemical and behavioral improvements on certain neurological disorders. This manuscript aims to highlight current research describing the use of statin therapy in the brain and discuss whether statins might affect neuronal dynamics and function independently of their cholesterol regulatory role.
他汀类药物是最常用的降脂药物之一。口服后，这些药物在肠道被很好地吸收，并有效地用于治疗血脂异常。最近，他汀类药物因其非胆固醇依赖性作用以及在脑部疾病和不同类型癌症中的潜在用途而广为人知。尽管仍存在争议，但最近的研究表明，他汀类药物的非胆固醇依赖性活性可能通过改变类异戊二烯水平而起作用。中枢神经系统中类异戊二烯的这种减少可能会对某些神经系统疾病产生有效的生化和行为改善。本手稿旨在强调当前描述他汀类药物在脑部治疗应用的研究，并讨论他汀类药物是否可能独立于其胆固醇调节作用而影响神经元动力学和功能。
