Pentney R J, Quackenbush L J, O'Neill M
Department of Anatomical Sciences, State University of New York, Buffalo 14214.
Alcohol Clin Exp Res. 1989 Jun;13(3):413-9. doi: 10.1111/j.1530-0277.1989.tb00346.x.
Dendritic networks of cerebellar Purkinje neurons from aging ethanol-treated Fisher 344 rats were analyzed for metric changes in terminal and internal segments of the networks. Mean lengths of three categories of dendritic segments were determined. No significant metric changes in segment lengths were detectable immediately at the termination of 24 weeks of ethanol treatment, but significant changes were apparent after 8 weeks of recovery from ethanol treatment. Return to a diet of standard laboratory chow was associated with a period of dendritic extension in networks from pair-fed control rats but not in those from the ethanol-treated rats. The resulting significant differences in mean segment length were restricted to the paired terminal segments at the peripheral tips of the bifurcating networks. Unpaired terminal segments and internal segments of the networks showed no significant changes in length during the recovery period.
对来自衰老的经乙醇处理的Fisher 344大鼠的小脑浦肯野神经元的树突网络进行分析，以研究网络末端和内部节段的度量变化。确定了三类树突节段的平均长度。在乙醇处理24周结束时，未检测到节段长度有明显的度量变化，但在从乙醇处理中恢复8周后，明显的变化就显现出来了。恢复到标准实验室饲料饮食与成对喂养的对照大鼠的网络中树突伸展期有关，但在乙醇处理的大鼠中则不然。由此产生的平均节段长度的显著差异仅限于分叉网络外周尖端的成对末端节段。在恢复期，网络的不成对末端节段和内部节段的长度没有显著变化。
