青少年特发性脊柱侧凸患者较低的肌肉量和体脂与瘦素生物利用度异常有关。
Lower Muscle Mass and Body Fat in Adolescent Idiopathic Scoliosis Are Associated With Abnormal Leptin Bioavailability.
作者信息
Tam Elisa M S, Liu Zhen, Lam Tsz-Ping, Ting Terry, Cheung Gordon, Ng Bobby K W, Lee Simon K M, Qiu Yong, Cheng Jack C Y
机构信息
Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, Hong Kong.
Joint Scoliosis Research Center of the Chinese University of Hong Kong and Nanjing University, Prince of Wales Hospital, Shatin, Hong Kong.
出版信息
Spine (Phila Pa 1976). 2016 Jun;41(11):940-946. doi: 10.1097/BRS.0000000000001376.
STUDY DESIGN
This was a case-control study.
OBJECTIVE
This study aimed to investigate the body composition and its correlation with leptin and soluble leptin receptor (sOB-R) levels in girls with adolescent idiopathic scoliosis (AIS) and compared with healthy controls.
SUMMARY OF BACKGROUND DATA
Patients with AIS are associated with lower body weight, taller stature, lower body mass index (BMI), and deranged bone quality. Despite the widely reported lower BMI and body weight in girls with AIS, the body composition of these patients was not thoroughly studied with sufficient sample size. Leptin is an important factor in regulating energy and bone metabolism, and has been postulated as one of the etiologic factors of AIS.
METHODS
One hundred forty-eight AIS and 116 control girls aged 12 to 14 were recruited. Body composition was measured with bioelectrical impedance analysis. Caloric intake and physical activity level were assessed by food frequency and Baecke questionnaires respectively. Serum total leptin and sOB-R levels were measured with enzyme-linked immunosorbent assay, and free leptin index was calculated.
RESULTS
AIS girls had lower body weight and BMI, other anthropometric and sexual maturity parameters were comparable with controls. There were no difference in caloric intake and physical activity levels. After adjustment for physical activity level, AIS girls had lower skeletal muscle mass, lower body fat, and %body fat. Higher sOB-R and lower free leptin index were found in AIS girls after adjusted for age and body weight. Weaker correlations between serum total leptin, FLI, and body composition parameters were observed in AIS girls.
CONCLUSION
Results suggested that the lower body weight in AIS girls was contributed by both lower skeletal muscle mass and lower body fat. Altered leptin bioavailability also exists in AIS girls and could lead to lower body weight, lower BMI, and abnormal body composition that were manifested in AIS simultaneously.
LEVEL OF EVIDENCE
研究设计
这是一项病例对照研究。
目的
本研究旨在调查青少年特发性脊柱侧凸（AIS）女孩的身体成分及其与瘦素和可溶性瘦素受体（sOB-R）水平的相关性，并与健康对照组进行比较。
背景数据总结
AIS患者体重较低、身材较高、体重指数（BMI）较低且骨质紊乱。尽管有广泛报道称AIS女孩的BMI和体重较低，但这些患者的身体成分尚未在足够大的样本量下进行深入研究。瘦素是调节能量和骨代谢的重要因素，被认为是AIS的病因之一。
方法
招募了148名年龄在12至14岁的AIS女孩和116名对照女孩。采用生物电阻抗分析测量身体成分。分别通过食物频率问卷和贝克问卷评估热量摄入和身体活动水平。采用酶联免疫吸附测定法测量血清总瘦素和sOB-R水平，并计算游离瘦素指数。
结果
AIS女孩的体重和BMI较低，其他人体测量和性成熟参数与对照组相当。热量摄入和身体活动水平没有差异。在调整身体活动水平后，AIS女孩的骨骼肌质量、体脂和体脂百分比较低。在调整年龄和体重后，AIS女孩的sOB-R较高，游离瘦素指数较低。在AIS女孩中观察到血清总瘦素、FLI与身体成分参数之间的相关性较弱。
结论
结果表明，AIS女孩体重较低是由于骨骼肌质量和体脂均较低。AIS女孩中也存在瘦素生物利用度的改变，这可能导致体重降低、BMI降低以及AIS中同时出现的身体成分异常。
证据水平
4级。
Zotero 插件