Department of Orthopaedic Surgery, Bonbarun Hospital, 343 Cheongun-ro, Mulgeum-eup, Yangsan 50611, Republic of Korea.
Department of Orthopaedic Surgery, BioMedical Research Institute, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan 49241, Republic of Korea.
J Clin Neurosci. 2020 Jan;71:124-128. doi: 10.1016/j.jocn.2019.08.106. Epub 2019 Sep 4.
To compare the serum levels of leptin and soluble leptin receptor (sOB-R) with adolescent idiopathic scoliosis (AIS) girls and controls through meta-analysis. The MEDLINE via PubMed, Cochrane, Scopus, and EMBASE database, from the earliest available date of indexing between January 2010 and January 2019, were searched for comparative studies evaluating serum levels of leptin and sOB-R in AIS girls. Two authors performed the data extraction independently. Any discrepancies were resolved by a consensus. Six comparative studies were identified. There was no statistically significant difference in terms of leptin between AIS girls and control [p = 0.19, WMD = -2.06 (-5.14, 1.03) ng/mL]. However, the sOB-R level was significantly higher [p < 0.00001, WMD = 2.85 (1.81, 3.88) ng/mL] and the free leptin index was significantly lower [p = 0.0006, WMD = -0.12 (-0.19, -0.05)] in AIS girls than those of healthy control girls. The body mass index was significantly lower in AIS girls [p = 0.03, WMD = -1.53 (-2.95, -0.12) kg/m]. The current meta-analysis showed that the level of sOB-R is higher in AIS patients than controls, while the concentration of leptin remains unchanged in AIS patients. Further well-designed studies would be necessary to substantiate our results.
通过荟萃分析比较青少年特发性脊柱侧凸（AIS）女孩和对照组的瘦素和可溶性瘦素受体（sOB-R）血清水平。通过 MEDLINE 中的 PubMed、Cochrane、Scopus 和 EMBASE 数据库，从 2010 年 1 月至 2019 年 1 月最早的索引日期进行检索，以评估 AIS 女孩瘦素和 sOB-R 血清水平的比较研究。两位作者独立进行数据提取。任何分歧均通过共识解决。确定了六项比较研究。AIS 女孩和对照组之间的瘦素水平没有统计学差异 [p=0.19，WMD=-2.06（-5.14，1.03）ng/mL]。然而，sOB-R 水平显著升高 [p<0.00001，WMD=2.85（1.81，3.88）ng/mL]，游离瘦素指数显著降低 [p=0.0006，WMD=-0.12（-0.19，-0.05）]。AIS 女孩的体质量指数明显较低 [p=0.03，WMD=-1.53（-2.95，-0.12）kg/m]。本荟萃分析表明，sOB-R 水平在 AIS 患者中高于对照组，而 AIS 患者的瘦素浓度保持不变。需要进一步设计良好的研究来证实我们的结果。
