Hansrani Vivak, Morris Julie, Caress Ann-Louise, Payne Katherine, Seif Mourad, McCollum Charles N
Institute of Cardiovascular Sciences, University of Manchester, Academic Surgery Unit, 2nd Floor, Education and Research Centre, University Hospital of South Manchester, Manchester M23 9LT, UK.
Institute of Population Health, University of Manchester, Department of Medical Education, 1st Floor, Education and Research Centre University, Hospital of South Manchester, Manchester M23 9LT, UK.
Eur J Obstet Gynecol Reprod Biol. 2016 Jan;196:21-5. doi: 10.1016/j.ejogrb.2015.10.023. Epub 2015 Nov 25.
Pelvic vein incompetence (PVI) affects 15-20% of all women, yet we know little about how it affects sufferers. The aim of this prospective pilot study was to explore symptoms experienced by women with PVI, and determine its impact on quality of life and NHS costs.
Case-control study at a UK University teaching hospital conducted over an eight-month period. Cases were 40 premenopausal women aged 18-49 years with PVI and varicose veins (VV). There were two age-matched controls groups: (i) 40 healthy women with no PVI but with VV, and (ii) 40 healthy women with no PVI and no VV. Subjects were asked to complete a structured questionnaire on disease specific outcomes, health status and use of healthcare resources.
Mean age (range) was 39.8 (24-47) years for cases, 39.1 (24-49) for VV controls and 38 (25-49) for healthy controls. Pelvic pain was reported by 38 of 40 (95%) PVI cases, compared with 25 of 40 (62%) VV controls, and 26 of 40 (65%) healthy controls (p=0.001). The median (range) EQ-5D utility score for PVI cases was 0.80 (0.29-1.0) compared with 0.80 (0.09-1.0) for VV controls and 1.0 (0.62-1.0) for healthy controls (p=0.002). Of the 40 PVI cases, 35 (88%) visited a consultant in the previous 12 months compared with 12 of 40 (30%) VV controls, and 14 of 40 (35%) healthy controls (p<0.001).
Women with PVI report a greater frequency of pelvic pain with reduced health status and increased use of healthcare resources compared with matched controls.
盆腔静脉功能不全（PVI）影响着15%至20%的女性，但我们对其如何影响患者知之甚少。这项前瞻性试点研究的目的是探究患有PVI的女性所经历的症状，并确定其对生活质量和英国国家医疗服务体系（NHS）成本的影响。
在英国一家大学教学医院进行了为期八个月的病例对照研究。病例为40名年龄在18至49岁之间的绝经前患有PVI和静脉曲张（VV）的女性。有两个年龄匹配的对照组：（i）40名无PVI但有VV的健康女性，以及（ii）40名无PVI且无VV的健康女性。受试者被要求完成一份关于疾病特定结果、健康状况和医疗资源使用情况的结构化问卷。
病例组的平均年龄（范围）为39.8（24 - 47）岁，VV对照组为39.1（24 - 49）岁，健康对照组为38（25 - 49）岁。40例PVI病例中有38例（95%）报告有盆腔疼痛，相比之下，40例VV对照组中有25例（62%），40例健康对照组中有26例（65%）（p = 0.001）。PVI病例的EQ - 5D效用评分中位数（范围）为0.80（0.29 - 1.0），而VV对照组为0.80（0.09 - 1.0），健康对照组为1.0（0.62 - 1.0）（p = 0.002）。在40例PVI病例中，35例（88%）在过去12个月内咨询过专科医生，相比之下，40例VV对照组中有12例（30%），40例健康对照组中有14例（35%）（p < 0.001）。
与匹配的对照组相比，患有PVI的女性报告盆腔疼痛的频率更高，健康状况更差，且医疗资源使用增加。
