Du Dan, Zhang Rui, Xing Zhihua, Liang Yuyan, Li Shengfu, Jin Tao, Xia Qing, Long Dan, Xin Guang, Wang Guangzhi, Huang Wen
Laboratory of Ethnopharmacology, West China Hospital/West China Medical School, Sichuan University, Chengdu 610041, China.
Laboratory of Ethnopharmacology, West China Hospital/West China Medical School, Sichuan University, Chengdu 610041, China.
Fitoterapia. 2016 Mar;109:20-4. doi: 10.1016/j.fitote.2015.11.022. Epub 2015 Nov 30.
Two new phenanthrene derivatives, 2,5,7-trimethoxy-9,10-dihydrophenanthrene-1,4-dione (1) and 2,5,6-trihydroxy-3,4-dimethoxy-9,10-dihydrophenanthrene (3), one new anthracenedione, 2,5,7-trimethoxyanthracene-1,4-dione (2), together with two known 9,10-dihydrophenanthrenes (4-5) were isolated from the rhizomes of Dioscorea zingiberensis C. H. Wright. The structures of these new compounds were established based on extensive NMR spectroscopy. Several isolated compounds were evaluated for the inhibition against nitric oxide (NO) production in the lipopolysaccharide (LPS)-activated RAW 264.7 macrophage cell line, DPPH radical scavenging, and inhibitory activity on Free Fatty Acids (FFAs) induced triglyceride accumulation in HepG2 cells. Compound 2 exhibited moderate anti-inflammatory activity, compound 3 possessed comparable DPPH radical scavenging activity as Vitamin C, compounds 2 and 4 showed potent inhibitory activities on triglyceride accumulation.
从盾叶薯蓣的根茎中分离得到了两种新的菲衍生物，2,5,7-三甲氧基-9,10-二氢菲-1,4-二酮（1）和2,5,6-三羟基-3,4-二甲氧基-9,10-二氢菲（3），一种新的蒽二酮，2,5,7-三甲氧基蒽-1,4-二酮（2），以及两种已知的9,10-二氢菲（4 - 5）。这些新化合物的结构通过广泛的核磁共振光谱得以确定。对几种分离得到的化合物进行了评估，考察其对脂多糖（LPS）激活的RAW 264.7巨噬细胞系中一氧化氮（NO）生成的抑制作用、二苯基苦味酰基自由基（DPPH）清除能力以及对游离脂肪酸（FFAs）诱导的HepG2细胞内甘油三酯积累的抑制活性。化合物2表现出中等程度的抗炎活性，化合物3具有与维生素C相当的DPPH自由基清除活性，化合物2和4对甘油三酯积累表现出强效抑制活性。
