Amirian E Susan, Armstrong Georgina N, Zhou Renke, Lau Ching C, Claus Elizabeth B, Barnholtz-Sloan Jill S, Il'yasova Dora, Schildkraut Joellen, Ali-Osman Francis, Sadetzki Siegal, Johansen Christoffer, Houlston Richard S, Jenkins Robert B, Lachance Daniel, Olson Sara H, Bernstein Jonine L, Merrell Ryan T, Wrensch Margaret R, Davis Faith G, Lai Rose, Shete Sanjay, Amos Christopher I, Scheurer Michael E, Aldape Kenneth, Alafuzoff Irina, Brännström Thomas, Broholm Helle, Collins Peter, Giannini Caterina, Rosenblum Marc, Tihan Tarik, Melin Beatrice S, Bondy Melissa L
Am J Epidemiol. 2016 Jan 15;183(2):85-91. doi: 10.1093/aje/kwv235. Epub 2015 Dec 10.
Decades of research have established only a few etiological factors for glioma, which is a rare and highly fatal brain cancer. Common methodological challenges among glioma studies include small sample sizes, heterogeneity of tumor subtypes, and retrospective exposure assessment. Here, we briefly describe the Glioma International Case-Control (GICC) Study (recruitment, 2010-2013), a study being conducted by the Genetic Epidemiology of Glioma International Consortium that integrates data from multiple data collection sites, uses a common protocol and questionnaire, and includes biospecimen collection. To our knowledge, the GICC Study is the largest glioma study to date that includes collection of blood samples, which will allow for genetic analysis and interrogation of gene-environment interactions.
数十年来的研究仅确定了少数几种胶质瘤的病因,胶质瘤是一种罕见且致命性很高的脑癌。胶质瘤研究中常见的方法学挑战包括样本量小、肿瘤亚型的异质性以及回顾性暴露评估。在此,我们简要描述国际胶质瘤病例对照(GICC)研究(2010年至2013年招募),这是一项由国际胶质瘤遗传流行病学联盟开展的研究,该研究整合了来自多个数据收集点的数据,采用通用方案和问卷,并包括生物样本采集。据我们所知,GICC研究是迄今为止最大的胶质瘤研究,其中包括血液样本采集,这将有助于进行基因分析以及探究基因与环境的相互作用。