Del Rosal T, García-García M L, Calvo C, Gozalo F, Pozo F, Casas I
Pediatrics Department, Hospital Universitario La Paz, Madrid, Spain.
Pediatrics Department, Hospital Severo Ochoa, Madrid, Spain.
Allergol Immunopathol (Madr). 2016 Sep-Oct;44(5):410-4. doi: 10.1016/j.aller.2015.07.004. Epub 2015 Dec 4.
Human bocavirus (HBoV) was recently discovered and identified as an important cause of respiratory infection in young children. However, the relationship between HBoV-bronchiolitis and the development of recurrent wheezing has not yet been established.
We designed this study in order to describe the mid-term outcome, regarding the development of recurrent wheezing and asthma of HBoV-bronchiolitis patients and to compare it with RSV-bronchiolitis infants.
We studied 80 children (10 with HBoV and 70 with RSV infection), currently aged ≥4 years and previously hospitalised during the seasons 2004-2009 due to acute bronchiolitis. Epidemiological and clinical data were collected through structured clinical interviews at the follow-up visit. Spirometry and skin prick tests to common food and inhaled allergens were performed.
All HBoV-patients developed recurrent wheezing and half of them had asthma at age 5-7 years. Almost 30% required hospital admission for recurrent wheezing. Asthma (odds ratio (OR)=1.28) and current asthma (OR=2.18) were significantly more frequent in children with HBoV-bronchiolitis than in RSV-bronchiolitis. FEV1 values were 99.2±4.8 in HBoV-group vs. 103±11 in RSV-group, p: 0.09. No differences were found with respect to allergic rhinitis, atopic dermatitis, food allergy, proportion of positive prick tests, and family history of atopy or asthma.
Severe HBoV-bronchiolitis in infancy was strongly associated with asthma at 5-7 years.
人博卡病毒（HBoV）最近被发现并确定为幼儿呼吸道感染的重要病因。然而，HBoV相关性细支气管炎与反复喘息发生之间的关系尚未明确。
我们开展本研究以描述HBoV相关性细支气管炎患者反复喘息和哮喘发生情况的中期转归，并与呼吸道合胞病毒（RSV）相关性细支气管炎婴儿进行比较。
我们研究了80名儿童（10名感染HBoV，70名感染RSV），这些儿童目前年龄≥4岁，曾在2004 - 2009年因急性细支气管炎住院治疗。在随访时通过结构化临床访谈收集流行病学和临床资料。进行了肺活量测定以及对常见食物和吸入性过敏原的皮肤点刺试验。
所有HBoV感染患儿均出现反复喘息，其中一半在5 - 7岁时患有哮喘。近30%因反复喘息需住院治疗。HBoV相关性细支气管炎患儿哮喘（优势比（OR）=1.28）和现患哮喘（OR = 2.18）的发生率显著高于RSV相关性细支气管炎患儿。HBoV组的第1秒用力呼气容积（FEV1）值为99.2±4.8，而RSV组为103±11，p值为0.09。在变应性鼻炎、特应性皮炎、食物过敏、点刺试验阳性比例以及特应性或哮喘家族史方面未发现差异。
婴儿期严重的HBoV相关性细支气管炎与5 - 7岁时的哮喘密切相关。
