清创术或微骨折术对前交叉韧带重建膝关节中伴发的全层软骨损伤患者报告结局的影响:一项来自挪威和瑞典的全国性队列研究,对357例患者进行了2年随访。

Effect on Patient-Reported Outcomes of Debridement or Microfracture of Concomitant Full-Thickness Cartilage Lesions in Anterior Cruciate Ligament-Reconstructed Knees: A Nationwide Cohort Study From Norway and Sweden of 357 Patients With 2-Year Follow-up.

作者信息

Røtterud Jan Harald, Sivertsen Einar Andreas, Forssblad Magnus, Engebretsen Lars, Årøen Asbjørn

机构信息

Department of Orthopedic Surgery, Akershus University Hospital, Lørenskog, Norway Institute of Clinical Medicine, Akershus University Hospital, Lørenskog, Norway

Diakonhjemmet Hospital, Oslo, Norway.

出版信息

Am J Sports Med. 2016 Feb;44(2):337-44. doi: 10.1177/0363546515617468. Epub 2015 Dec 11.

Abstract

BACKGROUND

The treatment of concomitant cartilage lesions in anterior cruciate ligament (ACL)-injured knees is debatable.

PURPOSE

To evaluate the effect of debridement or microfracture (MF) compared with no treatment of concomitant full-thickness (International Cartilage Repair Society [ICRS] grades 3-4) cartilage lesions on patient-reported outcomes after ACL reconstruction.

STUDY DESIGN

Cohort study; Level of evidence, 2.

METHODS

Six hundred forty-four patients who underwent primary unilateral ACL reconstruction and had a concomitant full-thickness cartilage lesion treated simultaneously by debridement (n = 129) or MF (n = 164), or underwent no treatment (n = 351) of the cartilage lesion, registered in the Norwegian and Swedish National Knee Ligament Registries from 2005 to 2008 were included. The Knee Injury and Osteoarthritis Outcome Score (KOOS) was used to measure patient-reported outcomes. At a mean follow-up of 2.1 ± 0.2 years after surgery, 357 (55%) patients completed the KOOS. Linear regression analyses were used to evaluate the effect of debridement or MF on the KOOS.

RESULTS

No significant effects of debridement were detected in the unadjusted or adjusted regression analyses on any of the KOOS subscales at 2-year follow-up. The MF treatment of the cartilage lesions had significant negative effects at 2-year follow-up on the KOOS Sport and Recreation (Sport/Rec) (regression coefficient [β] = -8.9; 95% confidence interval [CI], -15.1 to -1.5) and Knee-Related Quality of Life (QoL) (β = -8.1; 95% CI, -14.1 to -2.1) subscales in the unadjusted analyses. When adjusting for confounders, MF had significant negative effects on the same KOOS subscales of Sport/Rec (β = -8.6; 95% CI, -16.4 to -0.7) and QoL (β = -7.2; 95% CI, -13.6 to -0.8). For the remaining KOOS subscales of Pain, Symptoms, and Activities of Daily Living, there were no significant unadjusted or adjusted effects of MF.

CONCLUSION

MF of concomitant full-thickness cartilage lesions showed adverse effects on patient-reported outcomes at 2-year follow-up after ACL reconstruction. Debridement of concomitant full-thickness cartilage lesions showed neither positive nor negative effects on patient-reported outcomes at 2-year follow-up after ACL reconstruction.

摘要

背景

前交叉韧带(ACL)损伤膝关节合并软骨损伤的治疗存在争议。

目的

评估清创术或微骨折术(MF)与不治疗合并的全层(国际软骨修复协会[ICRS]3 - 4级)软骨损伤相比,对ACL重建术后患者报告结局的影响。

研究设计

队列研究;证据等级,2级。

方法

纳入2005年至2008年在挪威和瑞典国家膝关节韧带登记处登记的644例接受初次单侧ACL重建且合并全层软骨损伤的患者,其中129例软骨损伤采用清创术治疗,164例采用MF治疗,351例未对软骨损伤进行治疗。采用膝关节损伤和骨关节炎结局评分(KOOS)来衡量患者报告的结局。术后平均随访2.1±0.2年时,357例(55%)患者完成了KOOS评估。采用线性回归分析评估清创术或MF对KOOS的影响。

结果

在2年随访时,未调整或调整后的回归分析中,清创术对任何KOOS子量表均未检测到显著影响。在未调整分析中,软骨损伤的MF治疗在2年随访时对KOOS运动和娱乐(Sport/Rec)(回归系数[β]= -8.9;95%置信区间[CI],-15.1至-1.5)和膝关节相关生活质量(QoL)(β = -8.1;95%CI,-14.1至-2.1)子量表有显著负面影响。调整混杂因素后,MF对Sport/Rec(β = -8.6;95%CI,-16.4至-0.7)和QoL(β = -7.2;95%CI,-13.6至-0.8)相同的KOOS子量表仍有显著负面影响。对于其余的KOOS疼痛、症状和日常生活活动子量表,MF在未调整或调整后均无显著影响。

结论

ACL重建术后2年随访时,合并全层软骨损伤的MF对患者报告结局显示出不利影响。合并全层软骨损伤的清创术在ACL重建术后2年随访时对患者报告结局既无正面影响也无负面影响。

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