人初乳的颊部给药：对早产儿口腔微生物群的影响。
Buccal administration of human colostrum: impact on the oral microbiota of premature infants.
作者信息
Sohn K, Kalanetra K M, Mills D A, Underwood M A
机构信息
Division of Neonatology, Department of Pediatrics, University of California Davis, Sacramento, CA, USA.
Department of Food Science and Technology, University of California Davis, Davis, CA, USA.
出版信息
J Perinatol. 2016 Feb;36(2):106-11. doi: 10.1038/jp.2015.157. Epub 2015 Dec 10.
OBJECTIVE
To determine whether the administration of mother's colostrum into the buccal pouch in the first days of life alters the oral microbiota compared with control infants.
STUDY DESIGN
In this pilot study, 12 very low birth weight (VLBW) infants were randomly assigned to receive either colostrum from their mothers directly into the buccal pouch every 2 h for 46 h or standard care. We analyzed the oral microbiota at initiation and 48 and 96 h later using next-generation sequencing.
RESULT
The oral microbiota changed markedly over the 96 h period in all babies. Patterns of colonization differed between groups with Planococcaceae, the dominant family at 48 and 96 h in the colostrum group, and Moraxellaceae and Staphylococcaceae, the dominant families at 48 and 96 h, respectively, in the control group.
CONCLUSION
Buccal administration of mother's colostrum to VLBW infants influenced the colonization of the oral cavity with differences persisting 48 h after completion of the intervention.
目的
确定与对照婴儿相比，在生命最初几天将母亲的初乳注入颊袋是否会改变口腔微生物群。
研究设计
在这项初步研究中，12名极低出生体重（VLBW）婴儿被随机分配，一组每2小时将母亲的初乳直接注入颊袋，持续46小时，另一组接受标准护理。我们在开始时以及48小时和96小时后使用下一代测序分析口腔微生物群。
结果
在所有婴儿中，口腔微生物群在96小时内发生了显著变化。两组之间的定植模式不同，初乳组在48小时和96小时时的优势菌科为扁平球菌科，而对照组在48小时和96小时时的优势菌科分别为莫拉克斯氏菌科和葡萄球菌科。
结论
对极低出生体重婴儿颊部给予母亲的初乳会影响口腔定植，干预结束后48小时仍存在差异。
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