Department of Women's Health, Research Institute for Women's Health, Eberhard Karls University, Silcherstrasse 7/1, 72076 Tübingen, Germany; Department of Cell and Tissue Engineering, Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB), Nobelstrasse 12, 70569 Stuttgart, Germany.
Department of Women's Health, Research Institute for Women's Health, Eberhard Karls University, Silcherstrasse 7/1, 72076 Tübingen, Germany; Department of Cell and Tissue Engineering, Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB), Nobelstrasse 12, 70569 Stuttgart, Germany; Department of Medicine/Cardiology, Cardiovascular Research Laboratories, David Geffen School of Medicine at UCLA, 675 Charles E. Young Drive South, MRL 3645, Los Angeles, CA, United States.
Adv Drug Deliv Rev. 2016 Feb 1;97:260-9. doi: 10.1016/j.addr.2015.11.019. Epub 2015 Dec 3.
Regenerative strategies such as stem cell-based therapies and tissue engineering applications are being developed with the aim to replace, remodel, regenerate or support damaged tissues and organs. In addition to careful cell type selection, the design of appropriate three-dimensional (3D) scaffolds is essential for the generation of bio-inspired replacement tissues. Such scaffolds are usually made of degradable or non-degradable biomaterials and can serve as cell or drug carriers. The development of more effective and efficient drug carrier systems is also highly relevant for novel cancer treatment strategies. In this review, we provide a summary of current approaches that employ ECM and ECM-like materials, or ECM-synthetic polymer hybrids, as biomaterials in the field of regenerative medicine. We further discuss the utilization of such materials for cell and drug delivery, and highlight strategies for their use as vehicles for cancer therapy.
再生策略，如基于干细胞的治疗和组织工程应用，旨在替代、重塑、再生或支持受损的组织和器官。除了仔细选择细胞类型外，设计合适的三维（3D）支架对于生成仿生替代组织至关重要。这些支架通常由可降解或不可降解的生物材料制成，并可用作细胞或药物载体。开发更有效和高效的药物载体系统对于新型癌症治疗策略也非常重要。在这篇综述中，我们总结了目前在再生医学领域中使用细胞外基质（ECM）和类似 ECM 的材料或 ECM-合成聚合物杂化物作为生物材料的方法。我们还进一步讨论了这些材料在细胞和药物输送中的应用，并强调了将其用作癌症治疗载体的策略。
