Digestive Endoscopy Unit, Catholic University, Rome, Italy.
Dig Liver Dis. 2013 Jan;45(1):23-7. doi: 10.1016/j.dld.2012.07.011. Epub 2012 Aug 21.
4-L polyethylene glycol preparations are effective for colon cleansing before colonoscopy. However, large volume and unpleasant taste reduce tolerability and acceptability limiting patient compliance. A new isosmotic low-volume polyethylene glycol preparation with citrates and simethicone plus bisacodyl has been developed to improve patient compliance and tolerability.
To compare the efficacy of 2 different regimens of preparation vs a split-dose of polyethylene glycol solution.
In this randomised, blinded, comparative study, 153 patients were allocated to 3 arms. Arm 1 (n=52) received bisacodyl and 2-L polyethylene glycol with citrates and simethicone the day before the procedure. Arm 2 (n=50) received bisacodyl the day before and 2-L polyethylene glycol with citrates and simethicone on the day of colonoscopy. Control group (n=51) received a split-dose of 4-L polyethylene glycol. Cleansing was evaluated according to Ottawa scale.
The mean Ottawa score was not different in the 3 groups. Excellent cleansing was observed more frequently in arm 2 (70%) than in controls (49%) (p<0.05). No serious adverse events were observed in the 3 regimens. The willingness to repeat the same bowel preparation was superior in arms 1 and 2 than in controls (p<0.001).
New low-volume preparations seem to be as effective as the split 4-L polyethylene glycol regimen, showing a better tolerability and acceptability.
4-L 聚乙二醇制剂在结肠镜检查前用于结肠清洗是有效的。然而，大体积和不良口感降低了耐受性和可接受性，限制了患者的依从性。一种新的等渗低容量聚乙二醇制剂，含有柠檬酸盐和二甲硅油加比沙可啶，已被开发出来以提高患者的依从性和耐受性。
比较 2 种不同准备方案与聚乙二醇溶液分剂量的疗效。
在这项随机、双盲、对照研究中，153 名患者被分配到 3 个组。第 1 组（n=52）在检查前一天接受比沙可啶和 2-L 聚乙二醇柠檬酸和二甲硅油。第 2 组（n=50）在检查前一天和检查当天接受比沙可啶和 2-L 聚乙二醇柠檬酸和二甲硅油。对照组（n=51）接受 4-L 聚乙二醇分剂量。根据渥太华评分评估清洗效果。
3 组的平均渥太华评分无差异。第 2 组（70%）的优秀清洗率高于对照组（49%）（p<0.05）。3 种方案均未观察到严重不良事件。第 1 组和第 2 组再次接受相同肠道准备的意愿优于对照组（p<0.001）。
新的低容量制剂似乎与 4-L 聚乙二醇分剂量方案一样有效，表现出更好的耐受性和可接受性。
