Kasting N W
Department of Physiology, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Brain Res Brain Res Rev. 1989 Apr-Jun;14(2):143-53. doi: 10.1016/0165-0173(89)90012-x.
This paper has attempted to present and discuss the criteria necessary for the evaluation of a specific physiological role for a peptide in the CNS. These criteria are based on many experimental approaches to the problem and conclusions must be supported by the weight of the evidence. These criteria were illustrated by examining the hypothesis that AVP is an antipyretic neurotransmitter involved in regulating febrile increases in Tb by release and action in the VSA of the brain. The weight of the evidence in this case implies that this hypothesis is essentially correct. The only serious conflicting evidence comes from the work with Brattleboro rats. It is hoped that further research will resolve these discrepancies or result in a suitably modified hypothesis.
本文试图提出并讨论评估肽在中枢神经系统中特定生理作用所需的标准。这些标准基于解决该问题的多种实验方法，且结论必须有充分的证据支持。通过检验以下假说对这些标准进行了说明：抗利尿激素（AVP）是一种解热神经递质，通过在脑的腹隔区（VSA）释放和发挥作用来调节体温（Tb）的发热性升高。在这种情况下，充分的证据表明该假说基本正确。唯一严重冲突的证据来自对布氏大鼠的研究。希望进一步的研究能解决这些差异，或得出经过适当修改的假说。
