Joysey V C, Roger J H, Ashworth F, Bullman W, Hazleman B L, Lachmann S M, Watson P G
J Rheumatol Suppl. 1977;3:84-8.
Parallel studies were carried out on HLA antigens in patients with rheumatic heart disease and scleritis. Comparison with one control population showed a significant excess of BW15 in both disease samples, while a comparison with two other control populations, showed the excess not to be significant. Possible reasons for this discrepancy are discussed, together with the effect on statistical significance of a small percentage of false antigen assignments in one of the samples. A small systematic serological false assignment of an antigen can, by itself, produce a significant result more easily if the frequency of the antigen being detected is low than if it is high. It is suggested that this effect may contribute to the discrepant significant results obtained by different workers in some HLA and disease studies.
对风湿性心脏病和巩膜炎患者的 HLA 抗原进行了平行研究。与一个对照人群比较显示，在两个疾病样本中 BW15 均显著过量，而与另外两个对照人群比较时，该过量并不显著。文中讨论了这种差异的可能原因，以及其中一个样本中少量错误抗原分型对统计显著性的影响。如果所检测抗原的频率较低，那么抗原的少量系统性血清学错误分型本身就比频率较高时更容易产生显著结果。有人认为，这种效应可能导致了不同研究人员在一些 HLA 与疾病研究中得出的显著结果存在差异。
